Search for a trial

PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

Photoacoustic detection and monitoring of synovitis in finger joints with rheumatoid arthritis.

-To determine the feasibility of detection of synovitis by photoacoustic imaging using three discrete wavelengths of pulsed light as an early indicator of the presence of RA.-To correlate the photoacoustic markers that are indicative for…

A phase 1, open-label, 2-period, fixed sequence, study to investigate the absorption, metabolism and excretion of 14C-PF-06650833 and to assess the absolute bioavailability and fraction absorbed of PF-06650833 in healthy male subjects using a 14C-microdose approach.

The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…

Multicenter, open-label extension study to investigate the long-term safety and efficacy of IgPro20 in maintenance treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) in subjects completing study IgPro20_3003.

Primary objective: To evaluate the long-term safety of IgPro20.Secondary objectives: * To evaluate the long-term safety of IgPro20 by dose. * To evaluate the efficacy of IgPro20.Exploratory objectives:* To evaluate health-related quality of life (…

Identification of multiple potential triggers in sarcoidosis patients

To determine the prevalence of mycobacterial, propionibacterial and beryllium, aluminium and zirconium sensitized patients within a well-defined Dutch cohort of biopsy proven sarcoidosis patients.New clinico-pathological phenotypes within the group…

The effectiveness of a sports program on fatigue and QoL in IBD patients with quiescent disease

Primary Objective: - To assess the effectiveness of a sports program on fatigue and quality of life in IBD patients with quiescent disease and chronic fatigue.Secondary Objectives: - To assess the influence of a sport program on the physical fitness…

Immunological characteristics in UC patients that predict response on Vedolizumab

Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.

Systemic sclerosis: CT-derived evaluation of interstitial lung disease and pulmonary vasculopathy for assessment of progression of disease.
Research protocol for extended volume HRCT-thorax in patients with systemic sclerosis participating in a 2 *day multidisciplinary team care program of the department of Rheumatology and Pulmonology

zie nederlandse samenvatting

Extended systems medicine protocol to understand the development of psoriatic arthritis

Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…

FARAH study Fecal trAnsplantation to Reduce therapy-refractory graft versus host disease in Allogeneic Hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…

Immediate blood mediated immune response in immunocompromised recipients to islet infusion in vitro

- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients

The pathogenesis of vaginal dryness in women with primary Sjögren*s syndrome: a pilot study

Objective: Primary: To evaluate whether the vaginal mucosa of women with pSS shows histological signs of local inflammation. Secondary: A) To evaluate whether levels of pSS-related autoantibodies, (pro-inflammatory) cytokines and cellular markers,…

Evidence-Based Mindset & Physical Therapy for Add-on Treatment of Active Axial Spondyloarthritis: Safety and Efficacy

To investigate whether an add-on mindset & physical therapy program based on the *Wim Hof Method* can safely and efficaciously be applied in patients with active axial spondyloarthritis.

Effictiveness of the online self management training Reuma Uitgedaagd! for adults with a rheumatic disease

The objective is to study the effectiveness of the online self management training Reuma Uitgedaagd! voor adults with a rheumatic disease.

Training food-allergic patients to use their epinephrine auto-injector: a pilot study

Primary Objective:The primary objective of this study is to test the feasibility of methods and procedures prior to performance of a full-scale research project.Secondary Objective(s):The secondary objectives of this study are to determine whether…

Nutrition-based approach to support antigen-specific immunotherapy in subjects with cow's milk or peanut allergy

To study the immunomodulatory effects of non-digestible oligosaccharides using peripheral blood mononucleated cells isolated from blood of healthy controls and patients with peanut or cow*s milk allergy.

Assessment of the risk of foodallergy from mealworm consumption

- Establashing the percentage of patients within a population allergic to house dust mite and/or crustaceans, that can get an allergic reaction from consuming mealworm.- Establashing the risk of sensitization and allergy by handling mealworms and…

Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients

Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…

The effect of TNF blocking therapy on cardiac function in patients with active rheumatoid arthritis

Hypothesis - Our hypothesis is that TNF blocking medication improves cardiac function in patients with active RA. Objectives - Primary objective: to investigate the effect of TNF blocking therapy on diastolic left ventricular (LV) function in RA…

Generating normal values for antibody response in "healthy" patients of age

To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.