333 results
1. To determine, in patients treated with TNF α blockers and living in the Q-fever endemic area, the prevalence of antibodies against C. burnetii and the prevalence of chronic Q fever.2. To assess other determinants in this group of patients which…
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In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
To compare the expression of inhibitory receptors on immune competent cells in the airways of patients with allergic rhinitis, patients with infectious rhinitis. A secondary aim is to determine the relationship between inhibitory receptor expression…
The prevalence of anti-CCP in periodontitis patients.
Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
We will study the differences of nasal epithelial cells of patients who respond vs. who do not respond successfully to the immunotherapy for grass pollen. With this knowledge we can in the future predict or patients will respond successfully or not…
The lifespan of human neutrophils, eosinophils, basophils and monocytes under homeostatic conditions
The results of this study will lead to an improved insight in the lifecycle of these cells and our results will be of importance for more insight in chronic inflammatory diseases. For example, it will improve our ability to interpret the results…
To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.
To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.
Primary: We hypothesize that in eosinophilic esophagitis gastro-esophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic…
The objective of this study is to assess potentially new and unique biomarkers that will be specific to patients with HIDS as surrogate outcomes for eventual larger, cohort-controlled clinical studies. Our longitudinal design in a small pilot group…
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
The main hypothesis is that circulating inflammatory mediators are the main causative factor for the emergence of generalized osteoporosis in patients with Rheumatoid Arthritis (RA). 1.Does the serum of patients with active RA, containing…
To establish compare vessel wall dimensions and inflammation in AS with healthy matched control subjects with MRI and PET-FDG
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
The objectives of this initiative are:1. To establish the disease oriented biobank; processing and storage of blood and CSF specimens and health information of MS patients (which may include health records, family history, lifestyle and genetic…
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…