76 results
The primary objective is to set-up a well-defined sandwich ELISA method to measure the levels of Ara h6 in blood after peanut consumption.
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
Primary objectivesLongitudinal quantification of the total latent HIV reservoir with determination of the size of the replication competent HIV reservoir and investigate potential biomarkers of the HIV reservoir size and nature.Cross compare the…
DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-
To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.
Period 1: The first objective, of period 1, is to compare the safety and efficacy of ABT-494 30 mg (QD) and 15 mg QD versus placebo on a background of csDMARD(s) for the treatment of signs and symptoms of rheumatoid arthritis (RA) in bDMARD-…
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
De objective of this study is to analyse the effect of exercise on the levels of Ara h6 in the blood after peanut consumption. Next to this we would like to know whether these levels found are in associated with the measure of intestinal…
Primary objective: To identify specific bacteria or a characteristic bacterial composition in the oral and gut microbiome of pSS patients compared to non-Sjögren*s syndrome sicca (non-SS sicca) patients, SLE patients and healthy controls.Secondary…
The primary objective is to investigate quality of life after switch to a combination therapy including boosted DRV and DTG. Secondary objectives are to investigate 1) the residual viral replication, 2) level of virus production from infected cells…
This investigation aims to investigate connective tissue fibroblast activation in detail in the inflamed fibrotic connective tissue. By analyzing these cells in detail we hope to understand better how they are activated, so we can develop better and…
Primary objective- To explore the pharmacodynamic effects of topically applied IMQ (in combination with or without TS) - To identify dose-response relationship of topically applied IMQ Secondary objective- To assess safety and tolerability of…
To determine the prevalence and severity of ASA-related allergic reaction in SM patients.
To investigate whether an add-on mindset & physical therapy program based on the *Wim Hof Method* can safely and efficaciously be applied in patients with active axial spondyloarthritis.
This study has been transitioned to CTIS with ID 2024-518684-35-00 check the CTIS register for the current data. The current project proposal continues on our findings of the performed prospective cohort study, aiming to develop a biomarker guided…
Primary Objective:The primary objective of this study is to test the feasibility of methods and procedures prior to performance of a full-scale research project.Secondary Objective(s):The secondary objectives of this study are to determine whether…
Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…
- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
Primary objectiveTo evaluate the safety and tolerability of a single intra-articular administration of ART-I02, a recombinant adeno-associated virus (AAV) type 2/5 vector in subjects with RA and active arthritis in the wrist.Secondary objectives1.…