31 results
1. To determine biomarkers of response and non-response to treatment for active SLE in a prospective study where patients will be allocated to therapy according to current clinical practice and the EULAR guidelines (response biomarker study; 3TR SLE…
This study has been transitioned to CTIS with ID 2024-518966-28-00 check the CTIS register for the current data. The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial…
The aim of this study is to compare results of sensitization measurements (positive or negative) in skin test and blood test, with new nutritional proteins in food-allergic patients.
This study has been transitioned to CTIS with ID 2023-509710-11-00 check the CTIS register for the current data. Study Objectives:The purpose of this Phase 2 study is to evaluate the safety, efficacy, pharmacokinetics (PK),pharmacodynamics (PD), and…
The primary objective of this study is to collect blood samples (maximum of 150 mL per study visit ) from women and men who have SLE and from volunteers in good health to study the immune system of SLE patients and to investigate new potential…
1. To identify immunological alterations in peripheral lymphoid/skin/synovial tissue of patients with psoriatic artritis and psoriasis2. To correlate these alterations with disease stage, prognosis, treatment response3. To compare immunological…
Study GAL1039 (www.clinicaltrials.gov, NCT NL78487.000.21) is an Open Label study evaluating the safety, tolerability and effects of splenic nerve stimulation with Galvani's neuromodulation system. Since it is an Open Label study, the…
Primary Objective:Our primary objective is to generate in-depth immune profiles, which include phenotypic and functional analyses, as well as epigenetic and transcriptomic analyses, of several B cell, T cell, and monocyte subsets, which relate to…
This study has been transitioned to CTIS with ID 2023-508284-77-00 check the CTIS register for the current data. The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of gMG in adults with autoantibodies…
This study has been transitioned to CTIS with ID 2024-515832-59-00 check the CTIS register for the current data. To assess the long-term safety and tolerability of treatment with efgartigimod PH20 SC in participants with BP
In this proposal, we therefore aim to characterize in detail the cutaneous B cell response in patients with isolated CLE (CLE only) and patients with systemic and cutaneous disease (SLE/CLE). Primary Objectives: 1. Characterize autoreactive B cells…
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…
The main objective of this study is to evaluate the effect of anti-fibrotic/anti-SSc therapies using a SSc organ-on-a-chip (OoC) model. The secondary objectives of the study are:- To engineer an advanced OoC device to model SSc that incorporates key…
In this research proposal, we aim to develop chemical reporter molecules to study neutrophil activity and NET formation in real-time. We will systematically study the effect of brain-associated amyloid fibrils on NET formation and investigate the…
Primary Objectives: To unravel the immunological characteristics of postoperative recurrent CD and study the immunological changes in the IL-23 pathway following treatment with biological agents.Secondary Objectives:To study clinical, endoscopic and…
Primary Objectives- To evaluate disease-related characteristics and biomarkers in patients with CLE compared to healthy volunteers. Secondary Objectives- To evaluate the variability of the selected biomarkers between patients - To investigate the…
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
Primary objective: to investigate MPA exposure in a variety of autoimmune diseases in stable treated patients. Secondary objective: to develop predictive exposure models and evaluate the influence of population covariables on pharmacokinetics .The…
We aim to estimate the difference in effectiveness of DAS28CRP low disease activity and SDAI remission as treatment targets in RA treat to target strategies with regard to RA outcome.
Objective: The primary objective of this study is to investigate the potential of the custom global screening array (GSA) in patients with autoinflammatory disorders. We aim to investigate whether the GSA can pick up genetic variants in genes known…