19 results
Primary: To characterize the QGE031 dose response relationship for the increase in the threshold dose of peanut protein that induces objective hypersensitivity reactions after treatment.Secondary (only key parameters): The percentage of patients…
To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…
Primary objective:To investigate the effects of the three investigational products (1.Citrus e fructibus / Cydonia e fructibus as a whole, single preparations 2. Citrus e fructibus and 3. Cydonia e fructibus) on the changes in SAR related…
Objective: Determination of cross-reactivity to a newly developed PPD-derivative (F000175918) in previously PPD-sensitized patients. Hypothesis:Since PPD-derivative F000175918 is categorized as a moderate sensitizer, based on pre-clinical…
Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.
To analyse which allergens within cow's milk, peanut or nuts are most potent in activation of T cells and basophils.
To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.
To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.
Objective: How do T cells in cord blood respond to heat shock proteins, allergens and anti-CD3 Are stimulus specific Tregs induced during these responses and can these responses be suppressed by naturally occurring cord blood Tregs in vitro.
1. To investigate whether the currently used hay fever forecast correlates with the symptoms that grass pollen allergic patients report directly using a new communication system that allows direct control, and whether the model can be improved.2.…
The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols…
Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…
This is an exploratory study with two objectives:1. To investigate whether modification of allergenic milk and peanut proteins or peptides thereof with glycans can support oral tolerance induction by altering the antigen-specific T cell response…
The aim of the present study is therefore to investigate the bifidogenic effect of a hypoallergenic formula (based on partially hydrolysed whey protein) supplemented with a specific combination of prebiotics and probiotics (synbiotics) compared to…
Consuming Migo pear without getting allergic symptoms.
Gain a better fundamental understanding of the functioning of the human immune system.Our research focuses on the mechanisms involved in 2 aspects: 1. The induction of Tregs (and inhibition of Th2 cell polarization) by exposing DCs to certain…
Primary Objective: Evaluate the relationship between the amount of pollen collected in the environment of the hay fever sufferers using a handheld sniffer and the symptoms of these subjects.
This study's objective is to assess the bioavailability of phosphorus after oral intake of a new hypoallergenic infant formula compared to the bioavailability of phosphorus after oral intake of the current hypoallergenic infant formula.
This study investigates the preventive action of formula with partially hydrolysed cow milk protein supplemented with pre- and probiotics in the development of allergy. The goal of the study is to investigate the efficacy, the growth and the safety…