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A comparative in vitro study on the effects of the product Citrus e fructibus / Cydonia e fructibus as a whole and the single agent drugs Citrus e fructibus and Cydonia e fructibus separately, on immunological parameters of seasonal allergic rhinitis

Primary objective:To investigate the effects of the three investigational products (1.Citrus e fructibus / Cydonia e fructibus as a whole, single preparations 2. Citrus e fructibus and 3. Cydonia e fructibus) on the changes in SAR related…

Analysis of the potency of individual allergens in relation to IgE recognition in patients with cow's milk, peanut or nut allergy.

To analyse which allergens within cow's milk, peanut or nuts are most potent in activation of T cells and basophils.

Comparison of human milk extracellular vesicles in allergic and non-allergic mothers

To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…

Comparative research by means of skin prick test and provocation test between hypo allergenic Migo pear and Conference pear in patients with allergy to pear.

Consuming Migo pear without getting allergic symptoms.

Symptom scores and pollen monitoring by hay fever patients (SYMPOL)

Primary Objective: Evaluate the relationship between the amount of pollen collected in the environment of the hay fever sufferers using a handheld sniffer and the symptoms of these subjects.

Bioavailability of phosphorus after oral intake of hypoallergenic infant formula with additional phosphate sources in healthy adult volunteers with a neutral stomach pH.

This study's objective is to assess the bioavailability of phosphorus after oral intake of a new hypoallergenic infant formula compared to the bioavailability of phosphorus after oral intake of the current hypoallergenic infant formula.

An exploratory study to evaluate in vivo, ex vivo and clinical hypersensitivity reactions after first-time treatment with complement-reactogenic infusions

Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…

Modification of allergenic proteins with glycans for oral tolerance induction

This is an exploratory study with two objectives:1. To investigate whether modification of allergenic milk and peanut proteins or peptides thereof with glycans can support oral tolerance induction by altering the antigen-specific T cell response…

Blood collection to study and modulate dendritic cell-driven T cell responses

Gain a better fundamental understanding of the functioning of the human immune system.Our research focuses on the mechanisms involved in 2 aspects: 1. The induction of Tregs (and inhibition of Th2 cell polarization) by exposing DCs to certain…

A European multicenter, observational study to understand how the use of lebrikizumab affects health-related well-being and disease symptoms in patients with moderate-to-severe atopic dermatitis (ADTrust).

Primary objective: To assess the long-term effect of treatment with lebrikizumab on the overall well-being in patients with moderate-to-severe AD using the WHO-5 questionnaire. Secondary objectives: To assess the clinical effectiveness of…