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Pharmacokinetics and immunological aspects in nasal polyp patients treated with biologics: a pilot study

Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…

An Open-label, Multicenter Study to Assess the Safety, Pharmacokinetics and Pharmacodynamic Effects of THB001 in Adult Patients with Chronic Cold Urticaria

• To evaluate the safety and tolerability of THB001 in cold induced chronic urticaria patients

A randomized controlled trial to investigate the (cost)effectiveness of oral immunotherapy with different allergens in young children with an established food allergy.

What is the clinical- and cost-effectiveness of early low-dose oral immunotherapy aimed at long-term tolerance induction in children under the age of 30 months with an established food allergy compared to routine care?What is the effect of early low…

Comparative research between results of skin prick tests and prick to prick tests performed with fruit and vegetable extracts.

1. Are the results of the skin prick test (SPT) performed with homemade extracts and the prick-to-prick test (PTP) with fruit and vegetables comparable?2. Is there a difference in sensitivity and/or specificity between the SPT and PTP with fruit and…

A virtual, decentralised observational follow-up study investigating feeding patterns in infancy and the associated parent-reported allergic manifestations, allergies and infections in childhood.

Given the worldwide-observed rapid increase in the prevalence of allergic diseases, it is likely that environmental risk factors, including geographic area and lifestyle factors play a substantial role in the development of allergies and other…

Exploring the effectiveness of Itulazax on birch-related food allergy in adults treated with Itulazax for birch pollen allergy

The primary aim of this study is to investigate whether sublingual treepollen immunotherapy with Itulazax has an effect on food allergy-related quality of life in adults with tree pollen allergic rhinitis who also have a food allergy in the context…

Predictive model for the sensitising capacity of novel nutritional proteins.

Development of new in vitro assays with blood from well-characterized allergic donors.

Clinical validation of the NOVEOS immunoassay for allergy diagnostics

The aim is to evaluate the clinical performance of the system and verify the claims of reduced interference with biotin and CCDs. The measurements on NOVEOS will be mirrored in this study against the clinical diagnosis, the outcome of skin prick…

INflammation and cerebral small vessel disease (INSVD) study

To investigate the role of the immune and coagulation system on the progression of cerebral SVD

Acute immunotoxicological effects of traffic-related micro- and nanoplastics in urban air.

The main objective is to study presence of MNPs in blood and short-term changes in blood leukocytes, inflammatory markers and the anti-oxidant defence system, in association with traffic-related microplastic exposure in healthy young adults.…

Effect of an immune-supportive diet on gut permeability and allergic symptoms in children with peanut and/or nut allergy.

Therefore, the purpose of our study is to study, in peanut and nut allergic children:1. the relationship between gut permeability and threshold levels to peanut or nuts;2. the effect of an immune-supportive diet on gut permeability, coexisting…