184 results
Objective: Determination of cross-reactivity to a newly developed PPD-derivative (F000175918) in previously PPD-sensitized patients. Hypothesis:Since PPD-derivative F000175918 is categorized as a moderate sensitizer, based on pre-clinical…
Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…
To analyze whether the sensitization profile towards hazelnut, peanut and birch pollen and their major individual allergens can be used to predict whether the hazelnut allergy is associated without/with mild clinical symptoms or severe clinical…
Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.
To analyse which allergens within cow's milk, peanut or nuts are most potent in activation of T cells and basophils.
To compare the expression of inhibitory receptors on immune competent cells in the airways of patients with allergic rhinitis, patients with infectious rhinitis. A secondary aim is to determine the relationship between inhibitory receptor expression…
To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.
We will study the differences of nasal epithelial cells of patients who respond vs. who do not respond successfully to the immunotherapy for grass pollen. With this knowledge we can in the future predict or patients will respond successfully or not…
The lifespan of human neutrophils, eosinophils, basophils and monocytes under homeostatic conditions
The results of this study will lead to an improved insight in the lifecycle of these cells and our results will be of importance for more insight in chronic inflammatory diseases. For example, it will improve our ability to interpret the results…
To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.
ObjectivesPrimary Efficacy Objective• To assess the sustained clinical effect of BM32 during 2 consecutive treatment years compared to placebo. The clinical effect of BM32 is evaluated by a combined Symptom-Medication-Score (SMS) which is recorded…
To study the validity and usefulness of three immunological assays to improve knowledge on the course and diagnosis of sesame seed allergy in sesame seed allergic patients with proven anaphylaxis. In the first place, the CAP inhibition assay is used…
Primary: We hypothesize that in eosinophilic esophagitis gastro-esophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic…
The objective of the present study is to characterize the dose-response relationship of PURETHAL® Mites (PM) with a nasal provocation test in order to identify the optimal dose in terms of highest clinical efficacy and safety.
First, to estimate the cost-effectiveness of SCIT with tree pollen (TP), grass pollen (GP), and house dust mites (HDM) - the most prevalent allergies treated with SCIT - or combinations compared with UC. Second, to estimate the clinical efficacy of…
We seek to elucidate the immune mechanism(s) that are relevant for clinical tolerance to inhalant and food allergens. For this purpose, patients suffering from allergy to birch pollen and/or house dust mite who receive routine-SIT will be assessed…
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
Primary objective: To evaluate if the supernatant of allergen challenged basophils from non-systemic sensitized patients result in little, if any, activation of indicator basophils, whereas the supernatant of allergen challenged basophils from…
1) To identify chromosomal regions associated with the EoE-phenotype in a family with multiple affected family members. Subsequently these regions will be sequenced to detect causative gene(s).2) To describe the clinical characteristics of EoE-…
To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.