185 results
Objective: The response over time on daytime alertness and performance will be assessed following a single oral dose of bilastine 20 mg in healthy volunteers performing flying ability tests in a hypobaric chamber with an ambient pressure of 75.2 kPa…
To evaluate the efficacy of HDM-SPIRE in the reduction of symptoms and the use of allergy rescue medication associated with HDM allergy in subjects with clinically relevant symptoms.
The objectives of the study are as follows:Primary:• Part 1: To assess the pharmacokinetics and relative bioavailability of three different formulations of PA101 (4% cromolyn sodium with and without mannitol, and 6% cromolyn sodium without mannitol…
Multiple sensitizations were found using allergy tests, but most of the EoE patients have concurrent allergic diseases and the specific IgE found in serum apparently does not play a role in EoE pathogenesis. This theory is supported by the failure…
The aim of this pilot study is to validate potential biomarkers which diagnose patients who will benefit from asthma treatment with macrolide therapy by using non-invasively collected body fluid specimens. Th1/Th2/Th17 patterns in patients suffering…
The objective of this study is to test our hypothesis:Hypothesis - We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive *fingerprint* based on the combination of:…
To understand the development of immunological tolerance for allergens in young children.
The present study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of ARA 290 administered intravenously to healthy subjects, and of intravenously and subcutaneously administered ARA 290 to renally impaired subjects.
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
The study consists of three parts:a) Determine which specific components of a food allergen are important for (the severity of) the reaction.b) Developing a model to predict the severity of a food allergy using specific components (obtained from…
Primary Objective: 1) We want to investigate whether carriers of FLG-null mutations show higher responses to exposure to the skin irritant SLS than non-carriers.2) Furthermore, we want to investigate whether carriers of mutations in the genes coding…
To investigate the therapeutic effect of a selected probiotic mixture on the severity of AD in infants aged 0-15 months. The probiotic mixture has been studied in vitro and has proven IL-10 stimulating effects. Therefore it is thought to decrease AD…
Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…
To assess 1. the burden of allergic disease across Europe*s aging population2. the association of severe asthma with potential risk factors and their impact on lung function decline over time3. the association of asthma severity with sex hormone…
We hypothesize that expiratory VOC-analysis by electronic nose is capable of:1. Discriminating between asymptomatic infants and infants with respiratory wheeze.2. Discriminating between parent-reported and doctors-confirmed wheezy infants.The aim of…
Investigate the role of CD8+ T cells in AD by:a. Isolation of T cells from the skin and determination of the percentage and phenotype of CD8+ T cells in both acute and chronic AD, using the APT as an in vivo induction model. Comparison with…
Primary study objectiveTo investigate the prevalence of asthma in children up to 7 years of age with atopic dermatitis in infancy who received either Nutrilon Pepti with synbiotics or Nutrilon Pepti without synbiotics during 12 weeks in their first…
The primary objective of this study is to evaluate the effects of two types of AR treatment & placebo in counteracting AR*s effects on Cognition and Driving. Therefore, the effects of nasal provocation in AR patients on cognitive functions…