89 results
We hypothesize that an electronic nose can discriminate between the exhaled breath of patients with established pulmonary sarcoidosis from healthy controls Secondly, we hypothesize that an electronic nose can discriminate between different stages of…
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
The objective of this pilot study is to provide information about the usefulness of NIRS in the study of patients with JDM in the test configuration as described in the protocol. For this purpose, the microvascular oxygenation and hemodynamics in…
To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…
In this pilot study the effects of exercise on muscle energetics in the proximal muscle groups of the legs with patients with Juvenile Dermatomyositis will be cross-sectional studied. This will be done with an exercise test using a recumbent bicycle…
The identification of axial SpA in the primary-care setting and the introduction of questionnaires that could optimize the pattern of referral to secondary care is one of the most important objectives of the CAFASPA study.
The goals of this study is twofold:At first we want to gain insight in neurocognitive functioning of children and adolescents (12-18 year) with JSLE.Secondly, we want to adapt and validate a Dutch translation of a short "Quality Life…
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
to combine and validate diagnostic tests for the identification of preclinical very early RA (VERA) patients and prognostic tests for the prediction of progression
The objectives of this research study are to perform a biomarker development study for salivary pSS biomarker confirmation and panel building. The findings will be analyzed against SS diagnosis based on ACR criteria: Aim 1To test individual…
Primary objective:Pharmacokinetics/-dynamics of 124I-F8IL10 Secondary objective:Dosimetric parameters of arthritic joints and internal organs.
• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…
1. To image tissue biodistribution (joints, lymph nodes and internal organs) of rituximab in RA patients by [89Zr]rituximab PET-CT in RA patients with clinically active disease that will start rituximab treatment.2. To investigate whether…
1.To investigate if [18F]Fluoride PET-CT is a potential imaging technique for assessment of (changes in) disease activity of ankylosing spondylitis on baseline and after anti-TNF therapy (with MRI and clinical outcome as reference).Sub-study in 2…
To answer the following questionsDo RA-specific autoantibodies cross the placenta, and can they be found in fetal cord blood in the offspring of mothers suffering from RA?Do RA-specific autoantibodies in fetal cord blood display different…
The ulitmate goal of the current study will be the presentation of a specific minimum core set of outcome measures to be used in future clinical and follow-up studies in patients with autoimmune mediated polyneuropathies.
To evaluate the reproducibility of DCE-MRI measurement of the joints analyzed by color coded shape mapping, and by compartmental model analysis.
- To investigate different pathogenetic mechanisms underlying the clinical syndrome termed RA - To investigate changes in the synovial tissue in relationship to the duration of disease- To identify new therapeutic targets in the synovial tissue in…