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The effect of Alphabodies® against human lnterleukin lL23 in the transplant model of psoriasis, in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intradermally into the transplant.

Are Alphabodies against IL23 effecive in the transplant model of psoriasis

The effect of Spherical Nucleic Acids on target gene expression in full thickness biopsies taken from lesional skin of volunteers with psoriasis vulgaris.

The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.

Effictiveness of the online self management training Reuma Uitgedaagd! for adults with a rheumatic disease

The objective is to study the effectiveness of the online self management training Reuma Uitgedaagd! voor adults with a rheumatic disease.

Development of a psychological expectancy training - phase 3: pilot feasibility testing

With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.

A phase 1, open-label, 2-period, fixed sequence, study to investigate the absorption, metabolism and excretion of 14C-PF-06650833 and to assess the absolute bioavailability and fraction absorbed of PF-06650833 in healthy male subjects using a 14C-microdose approach.

The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…

Immunological characteristics in UC patients that predict response on Vedolizumab

Determine if there are immunological or patient characteristics in UC patients that predict the endoscopic response on Vedolizumab treatment.

Systemic sclerosis: CT-derived evaluation of interstitial lung disease and pulmonary vasculopathy for assessment of progression of disease.
Research protocol for extended volume HRCT-thorax in patients with systemic sclerosis participating in a 2 *day multidisciplinary team care program of the department of Rheumatology and Pulmonology

zie nederlandse samenvatting

Influence of Late Diagnosis on the Burden of disease in Adult Patients with Coeliac Disease.

The purpose of this study is to determine how diagnostic delay of CD affects the burden of CD to patients and society in terms of healthcare and mental healthcare utilisation and socioeconomic costs.

In vitro investigation into the potential regulating role of sphingolipids in lymphocyte proliferation.

More sustained knowledge of the intracellular processes regarding S1P in lymphocytes could be beneficial in modulating specific immune responses in transplantation medicine, autoimmune diseases and sepsis. Therefore, in this study, we will…

A randomised, double-blind, placebo-controlled trial for establishing safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of multiple subcutaneous doses of BI 655064 in healthy volunteers and in rheumatoid arthritis patients with prior inadequate response to methotrexate therapy

This study has two parts. The main purpose of Part 2 of this study is to see how safe and effective different doses of BI 655064 are as well as to look at the pharmacokinetics (the amount of medication in your blood) and the pharmacodynamics (the…

The effect of BS6.890C in the prophylactic transplant model of
psoriasis in which a psoriatic lesion is induced in non-lesional skin
transplanted onto immune-deficient (BNX) mice by injecting superantigen
activated peripheral blood cells intra-dermally into the
transplant.

The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.

Efficacy of a three novel compounds in a humanized mouse model of psoriasis

ln this study effect of 3 novel compounds on the development of psoriasis in the humanized mouse model isinvestigated. The efficacy is compared to one registered drug, namely Remicade(R).

Monocyte dysfunction in Multiple Sclerosis (MS)

1). Evaluate the expression of the genes encoding the enzymes that modify histones and DNA during monocyte differentiation in MS.2). Consequences of monocyte dysfunction for migration and cytokine/chemokine production.

Chronic disease in Immune Thrombocytopenia of Childhood

The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…

The Patient based Disease Activity Score (PDASII) validation study

The aim of this study is to assess the effect of training on the measurement properties of a recently developed disease activity score based on patient reported outcomes and to investigate if such a measure could be implemented in current clinical…

Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.

Characterization and extending the use of the humanized mouse model for psoriasis for pre-clinical testing of new drug.Limited screening of compound B for a pharmaceutical company.Therefore, depending on the success rate of transplantation and…

The effect of CD07813 in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting activated peripheral blood cells intra-dermally into the transplant. RD/10/15700

In previous projects a number of compounds were tested that had a positive effect in the transplant model of psoriasis. However, it proved difficult to prepare formulations that were stable enough to use in clinical studies. A new compound (CD07813…

Effectiveness of the online self management training ReumaUitgedaagd! for young adults with Juvenile Idiopathic Arthritis (JIA)

The objective of this research is to study the effectiveness of the online zelfmanagementtraining ReumaUitgedaagd! by young adults with Juvenile Idiopathic Arthritis (JIA) who are treated on the transition outpatient clinic of the departments…

The Neuropsychiatric Systemic Lupus Erythematosus Clinic, follow up visit

To evaluate efficacy and accuracy of diagnostic procedure in our NPSLE clinic and to evaluate effects of advised therapy by means of follow-up data

Efficacy of two novel compounds in a humanized mouse model of psoriasis

ln this study the effect of 2 novel compounds on the development of psoriasis in the humanized mouse model is investigated. The efficacy is compared to one registered drug, namely Stelera.