30 results
Primary objectivesLongitudinal quantification of the total latent HIV reservoir with determination of the size of the replication competent HIV reservoir and investigate potential biomarkers of the HIV reservoir size and nature.Cross compare the…
In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.
To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.
In this study we want to apply heavy water labelling to investigate how ageing affects the dynamics of different leukocyte populations.The main objectives of this study are:(A) to get more insight in the dynamics of an ageing immune system, in order…
Primary: To provide insight in the prevalence of diagnosed cases of IgG-subclass and/or antipolysaccharide antibodydeficiency in Dutch children. Secondary: To provide insight in the diagnostic process, the clinical presentation, the therapies used…
To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
To determine the replication history of DS-B-lymphocytes by KRECs in relation to somatic hypermutation.
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
Measuring the stability (and thereby half-life) of TRECs.
Clarifying the qualitative and quantitative aspects of the T cell response targeting and controlling polyomavirus BKV.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
In this study we intend to give the label "deuterium" to individuals as heavy water, to determine the turnover parameters of diverse leukocyte populations in health (young adults, healthy seniors of 60 years and older, healthy individuals…
Objective of this study is to determine the turnover of leukocyte populations in health (young, old) and how this compares to situations in which the immune system is disturbed ((HIV-1 infection, HSCT, thymectomy).
Hypothesis:- The height of the result of the MTB-specific assays is directly related to the number of MTB bacilli present. As a result, effective treatment of persons with LTBI will cause a decrease of the quantitative test result and finally a…
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
To characterize the interaction between the genetic background, the microbiome, and the immune responses in patients with diabetes type 1, both cross-sectional and over time, and to identify the disturbances in this interaction.
Investigation of the blood B cell compartment in family members of CVID patients (with and without a CVID family history) to identify or exclude B-cell defects and to improve our insight into a potential familial background of CVID.