31 results
The primary objective is to investigate quality of life after switch to a combination therapy including boosted DRV and DTG. Secondary objectives are to investigate 1) the residual viral replication, 2) level of virus production from infected cells…
Primary: to investigate the most importants determinants of the viral dynamics of low-level viremia. Secondary: to investigate the effects on immune activation, neurocognitive performance and periodontal status.
The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…
To determine the frequency of MBL and FCN SNPs in patients with a history of a proven gram-positive bacteremia, compared to patients without such history. A secondary objective is to determine whether extracorporeal circuits, used in cardiothoracic…
To assess the ex vivo cytokine production of whole blood during 28 days after phlebotomy (routine withdrawal of 500 ml of blood).
To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…
We will test a new theoretical model that assumes that mental health status interacts with the genetic factors influencing sympathovagal balance and the pro-inflammatory state. The results will be published in scientific magazines, and/or presented…
Using pedigree research in two CVID-families to find clues for genetic testing.
Primary Objective The prevalence and incidence of (pre)malignant and inflammatory pathology in the gastrointestinal tract of patients with a primary antibodydeficiency (CVID, XLA, IgG subclasse deficiency and abnormal vaccinationrespons). Secondary…
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
To examine the transmission of HIV variants.Have 1 or more viruses been transmitted?To examine the course of HIV-infection. Are differences in the course of HIV infection with same type viruses caused by genetic hostfactors Course more unfavourable…
1. To study the possible association between MBL-deficiency and the occurence and severity of infections in MBL-deficient CF patients.2. To study the possible association between MBL-deficiency and the severity of cystic fibrosis.3. To study the…
Immune regulation in Common Variable Immunodeficiency: the role of apoptosis and regulatory T cells.
To gain insight in the regulation of immune responses in patients with CVID
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
With this study, we want to gain insight in the SARS-CoV-2 specific immunity (T- and B-cell) of patients with congenital immune disorders. This will add to our knowledge on SARS-CoV-2 specific immunity, and on the immune capacity of the patients…
In this study it is aimed to investigate the genetic and immunological causes of VEO-IBD in order to improve diagnostics and therapies for patients with this intractable disease. In an explorative approach, state-of-the-art genome-wide screenings on…
The main goal of this study is to analyse NK cell phenotype in women with unexplained recurrent miscarriage in relation to their physical health.
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…