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An open-label randomised two-year trial comparing two first-line regimens in HIV-infected antiretroviral naïve subjects:
darunavir/r + tenofovir/emtricitabine vs. darunavir/r + raltegravir

Primary objective* To assess the non-inferiority of darunavir/r + raltegravir compared to darunavir/r + tenofovir/emtricitabine as first-line treatment strategies in HIV-1 infected, antiretroviral naïve adults over at least 96 weeks (i.e. to assess…

A multicentre, prospective, randomized open-label pilot study to assess the feasibility and preliminary efficacy of interferon gamma in combination with Anidulafungin for the treatment of candidemia

To evaluate the preliminary efficacy and feasibility of interferon gamma as adjunctive treatment in combination with the standard regimen, for the treatment of patients with candidemia using the following parametersSecondary objective: to evaluate…

*Kappa-deleting recombination excision circles* (KRECs) and somatic hypermutation (SHM) in Down Syndrome B-lymphocytes.

To determine the replication history of DS-B-lymphocytes by KRECs in relation to somatic hypermutation.

Genetic influences on autonomic nervous system activity and the pro-inflammatory state: the moderating role of mental health status.

We will test a new theoretical model that assumes that mental health status interacts with the genetic factors influencing sympathovagal balance and the pro-inflammatory state. The results will be published in scientific magazines, and/or presented…

Serum antibody response to influenza A in children with Down syndrome

Measuring specific antibody titers against influenza A (subtype H1N1 and / or seasonal vaccine) in DS children. DS anti-influenza antibody titers will be compared with controls available from the same laboratory.