24 results
The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…
To examine the effect of BCG as an adjuvant on DTP vaccination, and to investigate the non-specific training effects of BCG and DTP, alone and in combination, on the innate immune system.
Determine whether the prevalence of allergic sensitilization, defined as at least one allergen specific IgE with a concentration of >= 0,35 kU/l, is lower in people with than without DS. Analyse whether this prevalene is depending on age, how…
Objective: To analyze in more detail the complement activation and regulation and especially the functional CFH activity following three types of interventions in patients known with HUS and correlate these to clinical findings. The three…
The study is a diagnostic study for the diagnostics of sarcoidosis, in where a new, endo-sonographic procedure is compared to the current, bronchoscopic method.The objective is to assess the accuracy, safety and patient tolerance of endo-sonography…
We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…
Aim of the study is to evaluate wether exposure of HPA-1a negative fetuses to the maternal HPA-1a antigens during fetal life induces tolerance which may reduce the risk that HPA-1a antibodies are developed later in life.We postulate that 1) women…
Our purpose is to establish whether the frequently observed absence of tumor regression in the presence of infiltrating T lymphocytes is due to a lack of T cell effector function or due to an inhibitory influence of the tumor microenvironment on T…
To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.
Overall aim: To study the influence of M.leprae antigens on differentiation and maturation of DCs and to identify M.leprae antigens, receptors on antigen presenting cells and signaling pathways which play a role in leprosy pathology. Main objective…
Our primary objective is to investigate the effects of endotoxin-induced systemic inflammation and subsequent development of endotoxin tolerance on the inflammatory response following Fluenz® administration in vivo. To evaluate whether these effects…
Generation of (age-dependent) reference values **of leukocytes and their subtypes and of their products, as well as analysis of (age-dependent) IG / TR repertoire. In order to be able to distinguish the age-dependent effects from effects caused by…
Primary objectives• To evaluate complement activation after topical imiquimod challenge• To evaluate complement activation after local UV-B challenge
To obtain fresh mononuclear cells from healthy volunteer donors to be used for validation of procedures for the generation of GMP-grade T cell or tolerogenic dendritic cell products for clinical application.
The primary objective of this study is to quantify the dynamic properties of different leukocyte subpopulations in healthy skin and blood. Secondly, we aim to understand the relationship between leukocytes in skin and those circulating through the…
To test the hypotheses that patients who show severe fatigue after COVID-19 infection exhibit an exaggerated abnormal expression of inflammatory monocyte genes (particularly of the genes involved in pyroptosis, such as IL-1 and IL-6) as compared to…
We aim to describe the clinical characteristics and immune response in children seeking care for post-COVID complaints. Moreover, in a subset of children we evaluate the effect of the reinfection on clinical and inflammatory outcomes in children…
primary objectives- To asses sequelae of COVID-19, at 4 to 12-months following a COVID-19 diagnosis among pediatric patients receiving care in the hospital or outpatient setting in the Netherlands.- To determine risk factors for long-COVID among…
To assess whether premature aging of both the innate and adaptive arms of theimmune system are associated with COVID-19 morbidity and mortality. Identify immune (andendocrine) parameters that might be of use in predicting disease progression and…
In this study we aim to answer the question whether TCR diversity becomes limiting at older age and thereby leads to impaired responses to novel antigens. While many studies have suggested a contraction in TCR diversity with age, a one-to-one…