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A double-blind, randomized-withdrawal, placebo-controlled study to evaluate the efficacy and safety of human plasma-derived C1-esterase inhibitor as add-on to standard of care for the treatment of refractory antibody mediated rejection in adult renal transplant recipients

The primary objective of the study is to evaluate the efficacy of C1-INH in the treatment of refractory AMR in renal allograft recipients.The secondary objectives of the study are:1. To further evaluate the efficacy of C1-INH in the treatment of…

Neutrophil viability in surgical patients and its relationship with neutrophil functionality

This study aims to further investigate neutrophil viability as marker for neutrophil cell dead in patients with a decreased leukocyte viability factor and investigate its impact on neutrophil functioning.

Immune protective anesthesia during endoscopic colon surgery to improve long-term survival

Main objective: 1. Is there a 24hr-postoperative difference in immunological response between conventional and immune protective anesthesia?Secondary objectives:Is there a difference between patients with conventional and immune protective…

The effects of human endotoxemia on the functional capacity of hematopoietic stem and progenitor cells

Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…

Cell subsets in blood as a biomarker for Bronchiolitis Obliterans Syndrome (BOS)

The objective of this study is to determine the composition and functional capacity of leukocyte fractions in the blood of lung transplantation patients. As a possible biomarker for BOS. It is expected that in patients with BOS the frequency and…