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T cells and innate lymphoid cells (ILCs) in cutaneous graft-versus-host disease

The overall aim of the study is to improve our understanding of the role of T cells and ILCs in cutaneous GvHD, to lay the foundation for the development of better therapies to treat cutaneous GvHD.1. T cells in GvHDThe dominant cell population in…

Immune protective anesthesia during endoscopic colon surgery to improve long-term survival

Main objective: 1. Is there a 24hr-postoperative difference in immunological response between conventional and immune protective anesthesia?Secondary objectives:Is there a difference between patients with conventional and immune protective…

Protocol NKI-AVL: blood sampling of healthy volunteers for immunological research

To compare the immunobiology of healthy volunteers to (advanced) cancer patients to age-matched controls with no history of cancer and no potentially interfering medication.

The antibody response to pneumococcal vaccination in patients
with inflammatory bowel disease patients treated with immunosuppressive agents

Primary objective: to determine the vaccine efficacy of PCV13 plus PPV23 (2-month series) in cases, i.e. IBD patients treated with immunosuppressive agents, vs controls. Secondary objectives: - To assess if the use of a TNF-alpha inhibitor affects…

The effects of human endotoxemia on the functional capacity of hematopoietic stem and progenitor cells

Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…

Cell subsets in blood as a biomarker for Bronchiolitis Obliterans Syndrome (BOS)

The objective of this study is to determine the composition and functional capacity of leukocyte fractions in the blood of lung transplantation patients. As a possible biomarker for BOS. It is expected that in patients with BOS the frequency and…

A Phase 2a Proof-of-Mechanism, Open-Label Study to Determine the Effect of ACH 0144471 on C3 Levels in Patients with Low C3 Levels Due to Either C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

The Primary objective is to determine whether the administration of ACH 0144471 can increase C3 levels in patients with low C3 levels due to either C3G or IC-MPGN.The secondary objectives are:* To evaluate the safety and tolerability of ACH 0144471…

A randomized, double blind, placebo-controlled, double-dummy study to assess microneedle delivery in comparison to subcutaneous injection of adalimumab in healthy volunteers

1) To evaluate the pain, acceptability and local tolerability of intradermal microneedle injection compared to subcutaneous injection in healthy volunteers.2) To evaluate the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of…

Long-term follow-up of the offspring born to mothers with a solid organ transplant.

The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…

Dynamics of clonal hematopoiesis in pediatric stem cell transplantation recipients

We aim to define the growth trajectory of clonal hematopoësis after allogeneic transplantation, and identify potential modulating factors.