41 results
Primary objective;Confirm superiority of IgG antibody levels against pertussis toxin (Ptx), present in the acellular vaccines, in infants at the age of 3 months of mothers having received a pertussis vaccine during pregnancy versus infants of…
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
The main purpose of this study is to determine the appropriate age (10, 12 or 15 years) for a second MenC conjugate (MenCC) vaccine immunization in Dutch children that received a primary MenCC vaccination at a young age. A conclusion will be based…
To assess piperacillin concentrations during continuous dosing of P/T in critically ill patients; to determine PK variables, e.g. creatinine clearance, leading to a predictive mathematical model enabling TDM and ideally establishing better a priori…
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
The purpose of the study is to test whether a centre-wide policy of incremental antibiotic therapy will reduce arrhythmia device infection in patients undergoing arrhythmia device procedures compared to a policy of conventional antibiotic…
To investigate the Ertapenem plasmaconcentration time curves in a dosingscheme of three administrations per week after hemodialysis in patients with end stage renal disease depending on hemodialysis. To find a pharmacokinetic model to describe…
To assess the effect of alternative and reduced doses pneumococcal vaccination schedules using the 13-valent pneumococcal conjugate vaccine (PCV13, Wyeth) on the development of antibody titers directed against the different serotypes of pneumococci…
Primary: To determine trends in nasopharyngeal colonization with total vaccine- and non-vaccine serotypes of S. pneumoniae in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch National Immunization Program…
Primary: To compare immunogenicity (humoral and cellular) induced by PCV10 and PCV13 after the booster dose of a complete vaccination series (3+1, the current NIP schedule) Secondary: To compare immunogenicity (humoral) induced by PCV10 and PCV13 at…
The primary objective of this study is to provide an updated pharmacokinetic profile of orally administered nitrofurantoin in women aged 55 to 75 years.
The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…
To primary objective is to demonstrate a reduction in lipoteichoic acid release in patients with pneumococcal pneumonia treated with rifampicin. This will be done by measuring lipoteichoic acid in serum and urine.Evaluable patients for Intention-to-…
Primary objectiveTo determine the development of the cellular immune response (plasma B cells and memory B-cells), immediately before and after the booster of the 3+1 Prevenar® vaccination schedule at 11 months of age and before and after the…
Primary:To determine trends in vaccine- and nonvaccine-serotype S. pneumoniae asymptomatic colonisation in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch NIP with 7-valent pneumococcal conjugate vaccine…
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
Determine asymptomatic nasopharyngeal pneumococcal carriage and serotype distribution in elderly aged 65-70 years, 71-80 years ald 80 years and older. Assessment of the value of PCR compared with conventional culture methods.
Primary objective:To compare the change in small airways obstruction (FEF75%) in patients with CF when inhaling one ampule of inhaled tobramycin with the Akita® compared to standard of treatment (twice daily nebulization of one ampule using standard…
The main purpose of this study is to assess the long-term antibody responses and cellular memory immunity against B. pertussis in a cohort of Dutch children, 8-9 years of age, who have been vaccinated with aP in the first year of life. Furthermore,…
Investigate the effects of aP booster vaccination in children, young adults and elderly on the (long-term) immune response to B. pertussis in three European countries with a different epidemiological background and primary vaccination schedule for…