336 results
To assess clinical improvement of skin severity in patients with ichthyosis
Biomarkers For predicting disease Severity in Emergency department patients with suspected infection
Create a cohort of patients on the ED patients with a suspected infection, for the creation of a prediction model on mortality and disease severity using a combination of clinical parameters and biomarkers.
To investigate whether addition of a presepsin-guided step to the Dutch EOS guideline safely reduces unnecessary empirical antibiotic exposure directly after birth in preterm infants born <32 weeks gestation at moderate risk of EOS. Secondly…
Primary Objective: To study the early diagnostic performance of specific gene signatures for differentiation of patients having postoperative infection (A1) or sepsis (A2) from non-infected patients having postoperative SIRS (B1) and non-infected…
To assess the long-term clinical outcomes using Patient-reported Outcome Measures (PROMS), physical examination and radiological sequelae of acute septic arthritis in children.
To show proof of concept that humans indeed develop immunity to ticks.
Primary Objective: To investigate the yield of two methods of exhaled breath analysis (PCR based and VOC based) in the detection of Pseudomonas aeruginosa colonization or infection in young patients with cystic fibrosis (CF).Secondary Objective(s):…
To investigate whether the PK-PD target of cefuroxime (50%T>MIC) is attained in the first 24 hours of treatment in adult patients on general wards with adequate and impaired renal function receiving regular and reduced doses of cefuroxime.
The primary objective is to compare antibody responses against the pneumococcal vaccine strains and Influenza virus vaccine types in blood and saliva of older individuals with respect to frailty, taking sex differences into account. The overall aim…
The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…
Primary Objective: Exploring peri-operative changes in microbiota composition between patient receiving oral antibiotics, oral antibiotics with amphotericin B or no oral prophylaxis, performed by 16S rRNA sequencing, analyzed by Microbiome Center…
The objective of the proposed study is to determine the effectiveness, safety and cost-effectiveness of a strategy of cefuroxime combined with short course treatment with aminoglycosides compared to a strategy of ceftriaxone monotherapy in patients…
The aim of this study is to see whether we can safely use blood cultures more efficiently. By using a prediction model, we support the clinical decision to analyse a blood culture. If the chance that this culture yields a positive result is very…
This study has been transitioned to CTIS with ID 2024-513640-29-00 check the CTIS register for the current data. The aim of this study is to investigate the immune response to a primary and a booster immunization with a tetravalent MenACWY-TT…
To test whether valve surgery plus medical therapy is superior to medical therapy alone for treatment of endocarditis.
The aim of the present cohort study is to test the efficacy of pocket irrigation with a new pocket irrigation device for non-surgical treatment of peri-implantitis.
The main objective of the MeninGene study is to identify genetic risk factors in host and pathogen influencing susceptibility to bacterial meningitis, and the rate of complications, unfavourable outcome and death.
Identification of patients with a high risk of progression of premalignant gastric lesions, in order to compose guidelines for surveillance and follow up.
In this study we want to show adequate sputum levels are obtained throughout the day after inhalation of nebulized amoxicillin clavulanic acid in hospitalized AECOPD patients.
Could cytokines removal therapy by CytoSorb adsorber cause any improvement in the microcirculation?