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Procalcitonin as parameter for neonatal infection

Primary objective:- Determine whether PCT, measured in cord blood, and the blood of the neonate, is suitable to determine the presence or absence of neonatal infection.Secondary objective:- To investigate whether PCT is a suitable parameter to…

Pharmacokinetic evaluation and tolerability of dry powder tobramycin via the Cyclops® in children with cystic fibrosis

The main objectives are to investigate the pharmacokinetic properties of DP tobramycin via the Cyclops® at different dosages in children with CF, together with the local tolerability.

Long-term outcomes in immunologically low-risk kidney transplant recipients using tacrolimus.
Extension study of: Tacrolimus monotherapy in immunologically low-risk kidney transplant recipients: a pilot randomized-controlled study.

This study has been transitioned to CTIS with ID 2024-513394-42-01 check the CTIS register for the current data. To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus…

Strengthening memory immunity in the aged population by vaccinating pre-elderly

The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…

The Effect of Leukocyte DNA mEthylation and micRoBIOME diversity and function on host defense mechanisms during community-acquired pneumonia.

Primary Objectives: 1.To obtain insight in the role of altered DNA methylation in blood leukocytes (monocytes and neutrophils) in innate immune responses and host defense in patients with CAP.2.To determine the composition and function of the gut…

T-cell response in Lyme disease (TRIL-study)

Main objective: To determine the T cell response to Borrelia specific antigens using an ELISpot interferon gamma release assay in patients with different clinical presentations of Lyme and healthy volunteers.Sub-question 1: QuestionnairesTo analyze…

Histological and Microbiological Evaluation of Late Occurring Nodules with Hyaluronic Acid Dermal Fillers

Study Objective(s): To determine if HA dermal filler late occurring (> 4 weeks and < 2 years) nodules are associated with bacterial contamination (independent of filler type) and to characterize the histological response.

Influences of external determinants on the physiological development and composition of the infant microbiome in healthy infants from birth during the first 6 years of life using novel molecular techniques.
Subclinical and clinical disease, transmission, and risk factors of SARS-CoV-2 among children and their families: a household study within the "Microbiome Healthy Infant Study"

Primary objectives:1. To study the development of the infant microbiome, defined as the microbial communities in the nasopharynx (transnasal), oral cavity (saliva), skin and gastro-intestinal tract (faeces), in healthy infants born by vaginal…

Ciprofloxacin pharmacokinetics after IV and oral administration in cachectic elderly patients

Primary Objective: - To study the pharmacokinetics (CL, Vd, and F) of ciprofloxacin in cachectic elderly patients and compare with normal weight participants.Secondary Objective(s): - To assess the influence of covariates (such as TBW, LBW, serum…

Multiple doses versus single dose of cefazolin to prevent periprosthetic joint infection after revision arthroplasty: a multicenter open-label, randomized clinical trial

The aim of this multicenter open-label, randomized controlled trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.

CELAC and European consortium for a personalized medicine approach to Gastric Cancer (LEGACy)

Western Management strategies have been ineffective to modify the poor prognosis of GC. This proposal will focus on this specific challenge to *improve GC outcomes*, and will seek to gather evidence through international high-quality translational…

the effect of hyperbaric oxygen therapy on immune response and oxidative stress

To explore the effects of HBOT on immunologic parameters and oxidative stress.

Meningococcal vaccination in Dutch teenagers and adolescents: Study to investigate the long-term immune response after a tetravalent MenACWY-TT conjugate vaccine.

The aim of this study is to investigate the long-term immune response and determine the persistence of functional antibodies to the tetravalent MenACWY-TT vaccine administered as a second meningococcal vaccination after 5 years. This study will…

ABSORB-2:An exploratie study determining the oral antibiotic drug absorption in patients with short bowel syndrome.

The primary objective is to determine the absorption of orally administered antibiotics in patients with SBS, to guide in clinical decision making when faced with catheter related infections.

T cell respons in legionella

To evaluate the diagnostic potential of the elispot Legionella for identifying patients with Legionella disease

An open-label, single ascending dose study to evaluate the safety and pharmacokinetics of a tablet formulation of CG-549 in healthy subjects

The purpose of this study is to investigate how quickly and to what extent a new tablet formulation of CG-549 is absorbed and eliminated from the body. This information will be used to select a dose of CG-549 which is expected to be safe and…

Improved Diagnostic Strategies in Staphylococcus aureus bacteraemia

Primary objectives1. Determine prospectively the accuracy of proposed clinical criteria to assess the risk of SA-IE and complicated SAB2. Determine the diagnostic accuracy of cCT for SA-IE in patients with SAB3. Determine the diagnostic and…

Antibiotic prescribing and Non-prescribing in Nursing home residents with signs and symptoms Ascribed to urinary tract infection

To evaluate whether actively drawing physicians attention to the revised UTI guideline results in more appropriate AB prescribing for NH residents with suspected UTI. This will be achieved in two ways: 1) to incorporate the algorithm of the revised…

Efficacy of medicinal honey to reduce skin colonization of intensive care patients

Determine the efficacy of medical grade honey to reduce or prevent bacterial colonization at skin of intensice care patients.

Transmission Of Respiratory Tract microOrganisms In a School Environment

This study aims to provide insights into the processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections. Furthermore, this study will enable us to…