336 results
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
The first objective to investigate is the pharmacokinetics of DP tobramycin using the Cyclops® at four different dosages. The other objective is the local tolerability of DP tobramycin using the Cyclops® at four different dosages.
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
To determine the number of therapeutic first trough levels (vancomycin serum concentrations between 10 and 15 mg/L), when receiving a starting dose of 90 mg/kg/day. Furthermore, the number of subtherapeutic (serum concentration < 10 mg/L) and…
The primary objective of the study is to determine sensitivity, specificity, positive and negative predictive value of the enzyme analyses (myeloperoxidase, human neutrophil elastase and lysozyme) with wound biopsies as the gold standard.…
To determine the efficiency, safety and health care costs of a strategy using routine nebulisation of mucolytics and bronchodilators four times daily, with a strategy of nebulisation on a strict clinical indication only, in mechanical ventilated…
The purpose of the study is to test whether a centre-wide policy of incremental antibiotic therapy will reduce arrhythmia device infection in patients undergoing arrhythmia device procedures compared to a policy of conventional antibiotic…
(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
The purpose of the study is to investigate how quickly and to what extent GSK2251052 is absorbed, distributed, metabolized (converted) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be labeled…
Primary Objective: *To evaluate the immune responses 1 month after 3 doses of 13vPnC as measured by fold rises of serotype-specific immunoglobulin G (IgG) geometric mean concentrations (GMCs) in subjects *2 years of age. Secondary Objectives: *To…
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…
The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Primary objective: The primary objective of the study is to determine the effect of concentration/meditation on the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): There are two secondary objectives:1…
To determine the presence of ACPAs in patients with generalized severe periodontitis. Second objective is to assess RA development of ACPA positive periodontitis patients in the future.
The objective of the proposed pilot study is to explore acceptability and feasibility of structured and adequate symptomatic treatment in adult women with uncomplicated UTI.
To investigate the Ertapenem plasmaconcentration time curves in a dosingscheme of three administrations per week after hemodialysis in patients with end stage renal disease depending on hemodialysis. To find a pharmacokinetic model to describe…