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A Phase I, open-label, randomized, 3-way crossover study in 3 Panels of healthy, adult subjects to assess the relative bioavailability of TMC207 following single-dose administration of two pediatric formulations using a 100 mg tablet formulation as the reference, with and without food.

The primary objective is to assess the relative bioavailability of TMC207 after single-dose administration of 100 mg of TMC207 as water dispersible tablets or granules using a 100-mg tablet formulation as the reference, with and without food.

Sinonasal pathology in children with Cystic Fibrosis

Investigation of the prevalence of sinonasal disease on CT-sinus in children with Cystic Fibrosis at different ages. This study will focus especially on the onset of sinonasal pathology in Cystic Fibrosis in relation to the development of the…

Second meningococcal vaccination in Dutch children: Study to compare the tetravalent MenACWY-TT conjugate vaccine with the monovalent MenC-TT conjugate vaccine.

The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…

The effect of autonomic nervous system activity on the development of systemic immunosuppression and nosocomial infection in critically ill patients with brain injury

To examine the effect of parasympathetic and sympathetic nervous system activity on the systemic innate immune response and the incidence of nosocomial infections in patients with vascular or traumatic brain injury. A second objective is to…

Implementation of a cost effective strategy to prevent neonatal infection by group B-hemolytic streptococcus

To find the most cost effective GBS prevention strategy to reduce neonatal morbidity and mortality by GBS for the Netherlands.

Prevention of recurrent urinary tract infections by multi-drug resistant bacteria, by intravesical administration of gentamicin.

Objective: The main objective is to demonstrate superiority of the intravesical overnight instillation of gentamicin versus oral antibiotic prophylaxis in reducing the number of recurrences of UTI and extending the time-interval to a next UTI, in…

Changes in middle cerebral artery blood flow velocity during the early phase of fluid resuscitation in septic intensive care patients

Primary we aim to investigate whether the MCA blood flow velocity measured by TCD changes after initial fluid resuscitation in septic ICU patients, and secondly whether this MCA blood flow velocity has the ability to accurately predict fluid…

Feasibility analysis of nasoduodenal feces administration to eradicate resistant enterobacteriaeceae.

Primary objective is to investigate if donor feces infusion is effective in eradication of ESBL producing Enterobacteriaceae in the large intestine. Secondary objective is to determine whether ESBL decolonisation of the large intestine actually…

Pneumonia treated with rifampicine attenuates inflammation

To primary objective is to demonstrate a reduction in lipoteichoic acid release in patients with pneumococcal pneumonia treated with rifampicin. This will be done by measuring lipoteichoic acid in serum and urine.Evaluable patients for Intention-to-…

CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients.
The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study.

OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.

Splenic Artery Injuries and the need for Vaccination after Embolisation

To compare splenic function between patients who received splenectomy and patients treated with embolisation. Furthermore, splenic function between patients with different types of embolisation (proximal versus distal) will be compared

Tetanus post-exposure prophylaxis

The aim of this study is to find out whether TIG and revaccination prescription is in accordance with the immune status of a patient as measured by the TQS. Furthermore, the objective is to assess whether or not the TQS might be of additional value…

Immunisation of pregnant women with acellular Bordetella pertussis vaccine.

1) To test the feasibility of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in newborn babies.2) To test the safety of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in…

Transmission of Pseudomonas aeruginosa during an open air event for
Cystic Fibrosis patients

1. To investigate whether transmission of P. aeruginosa strains between CF patients occurs during a 1 day open air event and if so, whether there are patient-factors contributing to transmission. 2. To evaluate whether transmitted strains persist…

Prevalence of S aureus in nose and on (un)affected skin of patients visiting the outpatient department of Dermatology.

1) To determine the prevalence and the sensitivity for various antibiotics of Staphylococcus aureus in the nose (carrier) of patients visiting the outpatient department of Dermatology.2) To determine the prevalence and the sensitivity for various…

Analyses of pathogen and host determinants in hospitalized patients with a laboratory confirmed Staphylococcus aureus infection: The PATHOS Study

Objective: to study host and pathogen determinants of S. aureus infection to identify a putative antigen as target for the development of a prophylactic vaccine against S. aureus.

Neutrophil dysfunction and sepsis in ICU patients.

In previous studies we have identified specific receptor and surface protein expression profiles on neutrophils. Some of these profiles point at partially refractory neutrophils. In the current NERTHUS study we have seen that circulating neutrophils…

Cognitive bladder training versus rectal washout training for girls with recurrent urinary tract infections and urinary incontinence

Research question: is primary aggressive treatment of constipation with rectal wash-out in girls with NNBSD at least equally effective as usual care?

The protective role of the administration of antibiotics on the occurrence of sepsis after removal of ventral venous catheters in neonates.

To decrease the incidence of sepsis after removal of central venous catheters in the neonatal intensive care unit.

Cefazolin, 1 gram fits all?

Objective: 1) to assess whether adequate serum and interstitial fluid levels of cefazolin are reached during surgery in obese and non-obese patients, 2) to develop a population pharmacokinetic model for cefazolin which allows the characterization of…