336 results
In case of food- or water related outbreaks of bacterial gastroenteritis, the regular research of Municipal Health Services (GGD) and the Food and Consumer Product Safety Authority (VWA) aims at control of the outbreak.The aim of this project is to…
Determine asymptomatic nasopharyngeal pneumococcal carriage and serotype distribution in elderly aged 65-70 years, 71-80 years ald 80 years and older. Assessment of the value of PCR compared with conventional culture methods.
zie J. aanvullende opmerkingen
To determine and compare the periodontal status between the different groups of women. Periodontal examinations will be performed within one week after delivery. If periodontal disease is diagnosed within the selected groups, it is plausible to…
To investigate the gene and protein expression of neonates suffering from CoNS late-onset sepsis.
This proposal will investigate how and which immunosuppressive agents affect the innate immune response against infection. Understanding the impact of immunosuppressive agents on TLR-signaling and TLR-control may be a new focus for the development…
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
To validate a clinical decision rule to guide need for hospitalization in patients presenting with febrile urinary tract infection (FUTI) with the aim to reduce the hospitalization rate without compromising clinical outcome.
Primary objective:To compare the change in small airways obstruction (FEF75%) in patients with CF when inhaling one ampule of inhaled tobramycin with the Akita® compared to standard of treatment (twice daily nebulization of one ampule using standard…
To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.
Our study will measure several different symptoms/aspects of cellulitis, such as redness, swelling, warmth, pain, fluctuation, ulceration and drainage. Each of these aspects will be scored on a scale of 0-3, adding up to a maximum total score of 21…
The main objective of this study is to determine the number of therapeutic first trough levels (vancomycin serum concentrations between 10 and 15 mg/L), as well as subtherapeutic (serum concentrations < 10 mg/L) and supratherapeutic (serum…
Primary objective: To demonstrate that Positive Ct NAAT results 7, 21 and 49 days after (considered adequate) treatment of urogenital Ct with azithromycin is due to slow clearance of Ct RNA/DNA remnants (Ct culture negative) and not to therapy…
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction on the oral microflora, using the 16S next-generation sequencing technique.
a pilot study will be performed to gain understanding in cognitive functioning in patients with chronic Q-fever or QFS compared to matched controls.
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
To see whether C. burnetii is able to induce epigenetic changes in monocytes, resulting in a more distinct pro-inflammatory response to re-stimulation with viral particles, to see whether these changes are present in circulating monocytes of QFS…
To study alteration in platelet function and RNA transcripts during and after a Gram positive and Gram negative infections.
The aim of the study is to assess the feasibility of conducting a definitive trial in terms of recruitment, use and acceptability of H@H, quality of care and the advantages and disadvantages of H@H in comparison to usual hospital care.