78 results
To investigate the gene and protein expression of neonates suffering from CoNS late-onset sepsis.
This proposal will investigate how and which immunosuppressive agents affect the innate immune response against infection. Understanding the impact of immunosuppressive agents on TLR-signaling and TLR-control may be a new focus for the development…
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
To see whether C. burnetii is able to induce epigenetic changes in monocytes, resulting in a more distinct pro-inflammatory response to re-stimulation with viral particles, to see whether these changes are present in circulating monocytes of QFS…
To study alteration in platelet function and RNA transcripts during and after a Gram positive and Gram negative infections.
The quality and quantity of the innate immune response to bacteria should be tightly regulated leading to resolution of infection while minimizing damage to host tissue. We hypothesize that this regulation depends on gestational age at delivery and…
Aim of the study:To investigate the role of the CD200/CD200R axis on the responsiveness of whole blood, peripheral blood mononuclear cells (PBMCs) and neutrophils to a proinflammatory challenge in the immunoparalysed state in sepsis patients.…
Primary objective: To determine the added diagnostic value of the lytA qPCR on samples of the upper respiratory tract on top of routine microbiological tests in detecting pneumococci as responsible pathogen in patients with CAP.Secondary objective (…
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.
Identification of T cell epitopes that will serve as the basis for a novel Q fever vaccine with fewer side effects. This will be done by determining ex vivo the effect of Cb-derived T cell epitopes on IFN-γ production in blood of healthy volunteers…
To identify nasal microbial communities associated with Staphylococcus aureus carriage and study the influence over time of S. aureus-targeted decolonization treatment on these microbial communities
The primary objectives of the NO GBS study part 1 are to: - determine the clinical characteristics and outcome, and the prevalence of risk factors used by Dutch guidelines for risk assessment in GBS and E. coli meningitis and sepsis cases aged 0-3…
In this observational cohort study we will determine the prevalence and genetic profile of colonizing GBS isolates in pregnant women in the Netherlands. We will collect serum from pregnant women and their newborns to determine specific IgG…
We expect to provide evidence for our hypothesis stating that patients who develop infectious complications after trauma are characterized by a specific subset of circulating neutrophils displaying a reduced capacity to eradicate bacteria.…
Primary objective:- To evaluate the safety and tolerability of colonisation with non-toxigenic C. difficile.- To establish the effective protocol to obtain colonisation with non-toxigenic C. difficile in the majority of subjects.Secondary objective…
1) To establish associations between microbiome profiles and disease severity in patients with acute pancreatitis. 2) To establish associations between specific microbial shifts and infectious complications in the subgroup of patients with…
The project will aim to quantify very long-term sequelae after childhood BM (~31 years after infection) on a wide range of functional outcome domains: neurocognitive functioning, behavioral and emotional functioning, health related quality of life,…
This study is conducted to discover if bacterial vaginosis is related to the pregnancy rate in couples undergoing assisted reproduction.