25 results
To evaluate whether neuromuscular ultrasound discriminates between patients with and without ICU-AW.To detect differences between patients that do and do not have ICU-AW in order to determine relevant cut-offs which can be used in future diagnostic…
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
To describe the wound related complication rate in post-bariatric body contouring surgery patients who are treated according to a new guideline and assess the factors associated with a higher complication rate.
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
To examine the effect of BCG as an adjuvant on DTP vaccination, and to investigate the non-specific training effects of BCG and DTP, alone and in combination, on the innate immune system.
1) To determine whether vaccination with yellow fever results in a higher cytokine response upon restimulation in vitro with non-related infectious pathogens, compared to the response before the vaccination.2) To determine whether BCG vaccination…
To develop a screening test to predict ICU-AW at an early stage in patients admitted to the ICU. Also by prospectively following the patient group in time, this study aims to describe the natural history and functional limitations in patients…
1. Creating a reproducible and valid method for adenosine measurement2. Studying the effect of dipyridamole on the endogenous adenosine concentration before and after CPT.
The primary aim of this pilot-study is to assess safety and the effects on immune function in patients with septic shock of adjunctive therapy with IFN-gamma, in a placebo-controlled manner. The data obtained will allow us to do a powercalculation…
To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…
Primary Objective: To determine the sensitivity and specificity of MRI in a consecutive series of adult patients suspected for acute appendicitisSecondary Objective(s): Is MRI of additional value in adult patients with inconclusive US? And is…
Relation between mixed venous and central venous saturation in sepsis: influence of source of sepsis
Measurement in an observational setting of mixed en central venous oxygen saturations during the first 24 hours will provide interesting data. Not only can the influence of the sourse of sepsis on these data be described, but also the effect of…
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
To determine the general usefulness of and a proper moment when blood should be taken for the in vitro IFN-γ assays in patients undergoing chronic haemodialysis.
To determine the value of MRI in a consecutive series of pediatric patients suspected for acute appendicitis
Creating a reproducible and valid method for adenosine measurement
It is therefore planned to study pain perception in peripheral neuropathy in the context of positive and negative emotional stimulation. Although there is a recent plea for the study of emotional modulation of pain, only one study has as yet done so…
The objective of the study is to determine the prevalence of antibiotic resistant E. coli, S. aureus and K. pneumoniae strains in residents of Rotterdam visiting general practitioners in neighborhoods with low socioeconomic status (…
MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…
The aim of the study is to determine whether children who have been admitted to the ICU for an RSV infection in their first year of life and now are at school age:1. have more respiratory complaints than controls (based on a short questionnaire…