32 results
With this study we aim to provide insight in the role of pulmonary RAS in the pathogenesis of ARDS in neonates and children. This study is performed in the context of a comparative study assessing the impact of age on the pulmonary RAS in ARDS. We…
This study will investigate the value of C. burnetii-specific whole-blood IFNγ and IL-2 production assays in QFS patients that have either recovered, or are still substantially fatigued. This will show us if these assays can serve as potential…
This study will try to objectify if C. Burnetii is able to induce epigenetic changes in monocytes and macrophages, ultimately resulting in a changed cytokine profile. Subsequently, this study will try to link these epigenetic changes to mRNA…
Primarily, we aim to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance. To increase the chances of success, the genomic and transcriptomic data obtained in vivo will be integrated with data obtained by a…
We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH
Primary Objectives• Employ a systems biology approach to identify a set of candidate biomarkers (BM) in circulation and/or pathways & mechanisms that correlate with particular non-AIDS defining comorbidities (ie NASH, CVD) in HIV+…
Overall aimThe overall aim is to assess whether associations can be identified between the presence of oral/dental foci, the composition of the oral microbiome, the incidence and severity of OM, and the risk to develop FN in cancer patients treated…
We aim to analyze AMs of healthy volunteers using an integrative approach. Combining functional and phenotypical analyses with -omics based techniques can discover relationships across several cellular modalities, hereby providing an integrative…
In this study we aim to investigate which pathways in septic patients exacerbate endothelial injury and dysfunction, furthermore do we want to investigate to what extent, and due to which components plasma transfusion can improve the endothelial…
To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.
Achieving more detailed information about the possible auto-immune process that underlies narcolepsy by:(1) Assessing differences in immune composition between peripheral blood samples of healthy controls (n=30) and type 1 narcolepsy patients (n=30…
First objectives To assess the influence of apical periodontitis on the peripheral blood-plasma concentration of inflammatory mediators and to investigate the metagenome of root canal infections. Other objectives: To search for clusters and patterns…