53 results
To determine the efficacy and safety of laser therapy in diabetes patients with risk factors for developing diabetic foot complications.
Primary objective:1. To evaluate the frequency of invasive fungal infections in a prospective pediatric oncology cohort and to identify the determinants of such invasive infections.2. Clinical validation of novel innovative diagnostic methods for…
PrimairyTo clinically validate a finger prick DBS method compared to conventional venous sampling for the analysis of 5 immunosuppressive and 4 azole antifungal drugs in the pediatric population. Secondairy• Feasibility of the novel finger prick DBS…
Establish the pharmacokinetic parameters of micafungin in critically ill patients and determine whether pharmacokinetic parameters and plasma concentrations of micafungin correlate with disease severity.
The primary objective of this trial is as follows:• To determine the pharmacokinetics of anidulafungin administered to obese patients with a BMI >= 40 kg/m2. The secondary objective of this trial is as follows:• To simulate pharmacokinetics…
The objective of this study proposal is to determine whether pharmacologic optimization of voriconazole by means of therapeutic drug monitoring (TDM) results in improved patient outcomes (efficacy and safety) and is more cost-effective compared to…
Determine the pharmacokinetics of caspofungin, and the optimal dosage of caspofungin in relation to adequate exposure in critically ill patients.
The objective of this study is to obtain the absolute bioavailability of voriconazole in critically ill ICU patients.
- To investigate the safety and tolerability of posaconazole IV Solution (the test medication).- To study how the test compound posaconazole (the test medication) is absorbed, broken-down and excreted by the body. - To study the effect of the test…
to investigate whether the bioavailability of posaconazole in graft-versus-host-disease (GVHD) patients, adversely affected by the coadministration of proton pump inhibitors (PPIs), can be restored by an acidic beverage
Objective: The primary objective of this pilot study is to compare FDG-PET-CT with HR-CT alone and to HR-CT and galactomannan test together for early diagnosing IFIs in neutropenic patients.
To evaluate the preliminary efficacy and feasibility of interferon gamma as adjunctive treatment in combination with the standard regimen, for the treatment of patients with candidemia using the following parametersSecondary objective: to evaluate…
Prevalence of Tinea Pedis (athlete's foot) in people with intellectual disability in The Netherlands
Study into the prevalence of Tinea Pedis in intellectually disabled people who receive care from one of four care providers in The Netherlands, either living in the community or in a centralised location. Study into the prevalence of the different…
To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
The primary objective of this study is to evaluate the PK of POS administered orally at three dosage levels to immunocompromised children with expected neutropenia (selected oncology patients, aplastic anemia patients and patients which undergo a…
Primary Objectives:To assess the incidence and the time to confirmed IFI in subjects treated pre-emptively with micafungin versus placebo.
The study described in this protocol is designed to determine the pharmacokinetics of cefotaxime and its metabolite, desacetyl-cefotaxime, in children on continuous intravenous infusion of cefotaxime. Using these data we will be able to delineate…
This study aims to determine whether variations in genes encoding the most important components of the innate immune system (gene polymorphisms), play a role in the susceptibility to recurrent vulvovaginal candidiasis.
The primary objective of this trial is as follows:• To determine the pharmacokinetics of anidulafungin given once in every 2 days (q48h) or once in every 3 days (q72h) to patients undergoing an allogeneic haematopoietic stem cell transplant…