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Prevalence of Tinea Pedis (athlete's foot) in people with intellectual disability in The Netherlands

Study into the prevalence of Tinea Pedis in intellectually disabled people who receive care from one of four care providers in The Netherlands, either living in the community or in a centralised location. Study into the prevalence of the different…

T-cell mediated immunity against Aspergillus fumigatus

To study the mechanisms by which T-cells can contribute to the defense against Aspergillus fumigatus.To study the role of the immune system and the role of Aspergillus antigens in the switch from a Th1 to a Th2 profile in patients with ABPA.

Contribution of genetic factors to recurrent vulvovaginal candidiasis

This study aims to determine whether variations in genes encoding the most important components of the innate immune system (gene polymorphisms), play a role in the susceptibility to recurrent vulvovaginal candidiasis.

Influenza-associated pulmonary aspergillosis (IAPA) in ICU patients with severe influenza: incidence and host- and pathogen related risk factors

A prospective multi-center observational study to assess the incidence of influenza-associated pulmonary aspergillosis (IAPA) in ICU patients and to identify host- and pathogen related risk factors for IAPA in EORTC negative ICU patients with severe…

Immunological Defects in Chronic Pulmonary Aspergillosis

In this study, we aim to characterize the immunological defect in patients with CPA as compared to patients with chronic obstructive pulmonary disease (COPD) without CPA on a functional, genetic, transcriptional and metabolic level.

A phase IV, interventional, non-blinded, randomized, controlled, multicenter study of posaconazole prophylaxis for the prevention of influenza-associated aspergillosis (IAA) in critically ill patients

To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…

Fungal infections as complication of monoclonal antibody therapy directed against IL-17 mediated inflammation: estimating incidence and severity and identifying influence of immunogenetics to establish a guideline for screening, prevention and treatment.

1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…