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Diagnostics and mechanisms of titanium allergy

Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…

Game Ready continuous-flow cryo- and cyclic compression therapy after fracture treament of the hip: a prospective multicenter, open-label, multicenter, randomized, controlled, clinical trial on postoperative effects on pain.

The goal of the study is whether to establish if application of combined cyrocompression therapy directly postoperative after hip fracture surgery results in a significant reduction in painperception en whether this reduces the morfine consumption.…

The effect of Caphosol on the development of esophagitis in (N)SCLC patients treated with concurrent chemo/radiotherapy

Trial hypothesisAdding the use of Caphosol® (rinsing and swallowing four times a day) to the standard of care for esophagitis/mucositis, reduces the incidence, onset, duration and severity of esophagitis in (N)SCLC patients, comparing to the…

Decongestants for dilating the nasal cavity, a randomised, blinded, prospective study to prevent iatrogenic epistaxis during nasotracheal intubation

Primary Objective:The purpose of this study is to investigate the clinical efficacy of xylomethazoline, combined with dilating the nasal passage way with a polyvinyl-alcohol nasal dilator in the prevention of iatrogenic epistaxis during nasotracheal…

Local gentamicin in Redon treated post-sternotomy mediastinitis

The aim of our study is to evaluate clinical outcomes of patients primarily closed over Redon catheters for the treatment of PSM, comparing the application of local gentamicin with a control group.

Postoperative cognitive dysfunction in elderly cancer patients

In this pilot study experience will be obtained in diagnosing POCD and its risk factors, in elderly surgical cancer patients.

Potential Carcinogenic Effects of Endovenous Laser Ablation

This study will determine the concentration of benzo[a]pyrene before and after EVLA.

Forces exerted on upper and lower teeth during intubation: a randomized crossover trial comparing indirect videolaryngoscopy to direct laryngoscopy

Measuring the forces exerted on upper en lower teeth during classic (direct) and (indirect) (video)laryngoscopy.

Epiglottic downfolding during endotracheal intubation* An alternative technique to improve glottic exposure, and facilitate intubation?

We want to determine if epiglottic downfolding leads to a better view of the glottis and more successful intubations. We also want to investigate if this comes at the cost of more postoperative sore throat, dysphonia, dysphagia and coughing…

Early Detection of Anastomotic Leakage after Colon, Esophageal and Gastric Surgery

Primary objective:To find a relation between several laboratory test, clinical parameters and riskfactors to the occurrence of anastomotic leakage after a colectomy, esophagectomy or gastrectomy.Secondary objective:To find a combination of factors…

Oropharyngeal space in videolaryngoscopy: a randomised crossover trial measuring remaining space adjacent to the video laryngoscope blade.

Measuring the space on the right side of the videolaryngoscope blade and the palatopharyngeal wall in a cohort of ASA I-III patients with a normal mouth opening (Mallampati I, II and III). We also want to investigate how this space differs from the…

Vocal cord pathology after short term intubation

First objective; to document the existence and to categorize vocal fold pathology after short term intubation and to study voice related patient complaints after short term intubation. Second and third objective; to study the pattern/type of injury…

Randomised controlled trial comparing the LFN (Lateral Femoral Nail) to the UFN (Unreamed Femoral Nail) in the treatment of femoral shaft fractures.

1 Confirm comparable results in reduction and consolidation of the fracture fragments using the LFN vs the UFN2 Identifying a significant difference in the soft tissue damage between the LFN and the UFN

Bile suppletion as adjuvant therapy in the treatment of iatrogenic bile duct injury after cholecystectomy: a bitter necessity?

The primary study objective is to investigate the contribution of peri-operative suppletion of bile to the preservation of bodyweight (expressed in kilograms).Secondary study objectives:1.To determine the contribution of peri-operative suppletion of…

Ultrasound guided versus nerve stimulation guided distal sciatic nerve block

We hypothesize that ultrasound visualization of the distal sciatic nerve with subsequent ultrasound guided injection of a reduced amount of local anesthetic will result in shorter performance times, equivalent block quality (sensory and motor onset…

Correction of Sub-clinical Prolongation of COAGulation Tests and/or Low Platelets before TRACHeotomy
- Randomized controlled trial *

To determine if patients with sub-clinical lengthening of coagulation test, low platelets or use of Ascal have increased risk of clinical significant bleeding during and after tracheotomy.

Chronic post-sternotomy pain, relation between accompanying painsymptoms and painlocation on the sternum

The objective of this study is to prove that chronic post-sternotomy pain is not a local painproblem, but part of a general painsyndrom.Our hypothesis is twofold:1. The investigated painsymptoms are of more frequently occurrence in the pain-sample…

Primary Closure of the lower limb and chest wound with Steri strip S in comparison with inter-cutane sutures in patients undergoing CABG.

To investigate whether application of Steri-Strip* S will lead to: 1) shorter treating time 2) improved satisfaction with the patient 3) improved wound healing4) improved cost-efficiency5) improved satisfaction with the attendant

Prevalence, severity and origin of lymphedema among women five years after treatment for breast cancer.

The primary goal is investigating the number of women that have lymphedema five years after the treatment for breast cancer. In the describing part of this study, the focus will be on the correlation between lymphedema and 1) surgical treatment, 2)…

Effect of postoperative negative pressure wound therapy (Prevena TM) in clean closed surgical incisions on the incidence of wound dehiscence in low and high risk patients: a rondomized controlled pilotstudy.

The aim of this study is to compare the effect of a postoperativenegative pressure dressing (Prevena (TM) IMS) with a standardwound dressing (care as usual) in clean closed surgical wounds on the prevention of wounddehiscence in low riks and high…