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A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN-74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC)

To assess the safety and tolerability of PLN 74809 in participants with PSC and suspected liver fibrosis

Serum glycomics as prognostic and diagnostic biomarkers of graft loss and hepatocellular carcinoma recurrence in liver transplant recipients

Primary Objective: * To validate the prognostic value of a serum glycomics biomarker for graft survival at 3 months after liver transplantation. * To validate the prognostic value of a serum glycomics biomarker for overall survival at 3 months after…

The pre-post differences in nutritional intake, information needs, motivation, lifestyle, clinical outcomes and fatigue symptoms of MASLD patients, and their engagement and adherence to the serious game: a pilot study.

To determine the effect size of the difference in nutritional intake (carbohydrates, calories, fiber) of MASLD patients before and after playing the serious game. In addition, information provision, information needs, physical activity, response…

HARMONY

To demonstrate the feasibility of single session minimally invasive concurrent robotic liver resection and cone beam CT-guided percutaneous ablation of colorectal liver metastases in a hybrid operating room and evaluate its outcomes.

WIDE study

Objective: To identify and characterize WD patients in the Netherlands. Secondary objectives of this study are; describe disease management and treatment patterns, examine treatment adherence and efficacy of current treatment options, gain insight…