Search for a trial

The use of perioperative antibiotic prophylaxis in the treatment of acute cholecystitis, a randomized, multicenter, non-inferiority trial

To provide high level of evidence that omitting perioperative antibiotic prophylaxis does not increase the postoperative infection rate, in patients with acute calculous cholecystitis undergoing laparoscopic cholecystectomy.

Scrutinizing (in)efficient use of cholecystectomy: a randomized trial concerning variation in practice.

Current practice variation in selection of patients with gallbladder stones and abdominal complaints for cholecystectomy is not efficient. Here we evaluate stepwise selection for surgery to improve patient outcome and to reduce the number of…

Kumar clamp versus Olsen cAtheter for Laparoscopic intraoperative cholAngiography (KOALA)

To assess whether cholangiography using the Kumar clamp is faster and easier than using the Olsen catheter.

Diagnostic accuracy of MRI for gallbladder polyps;
a prospective diagnostic pilot study

Primairy objective: To determine the diagnostic accuracy of MRI for the (differential) diagnosis of GB polyps and the differentiation between true and pseudo polyps in patients with suspected GB polyp(s) on previous imaging modality (TAUS) by using…

Acute cholecystitis in high risk patients: percutaneous cholecystostomy versus laparoscopic cholecystectomy; a randomized controlled, open, parallel, superiority, multicenter trial

To demonstrate that primary LC as compared to PC is preferable with respect to morbidity and mortality in high risk surgical patients (APACHE-II score 7-14) with acute calculous cholecystitis.

Evaluation of the Follow me mode of the AutoLap system- a feasibility study

The main objectives of this study are to evaluate the performance and ease of use of the Follow me mode of the AutoLap system during general and gynecological laparoscopic procedures.Study Procedures: No. & type. A total of 35 laparoscopic…

Long term effect of bile duct injury in gallbladder surgery.

Evaluation of quality of life and resoration of function after bile duct injury.

Perioperative antibiotic use in the treatment of acute calculous cholecystitis

To demonstrate that extended postoperative antibiotic treatment does not decrease the infectious complication rate in laparoscopic cholecystectomy for acute cholecystitis.

Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.

This study is designed to provide evidence regarding the prophylactic use of UDCA in preventing symptomatic gallstone disease after RYGB and Sleeve Gastrectomy.

Understanding the Pathophysiology of metabolic dysfunction-associated steatotic liver disease and Metabolic Syndrome Following Cholecystectomy*

The aim of this study is to explore the biological and microbial alterations after cholecystectomy that contribute to the pathophysiology of metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD).

Double-blind, randomized, placebo-controlled, phase II dose-finding study comparing different
doses of Rhudex granules with placebo in the treatment of primary biliary cholangitis

Primary:To evaluate the efficacy of 3 doses of RhuDex vs placebo for the treatment of PBC in patients with an inadequate response to UDCA.Secondary:• To identify efficacious RhuDex dose(s) for the treatment of PBC for further evaluation in phase III…