88 results
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…
To evaluate the effectiveness and safety of concentration controlled combination of once daily dosed low-dose sirolimus (trough levels: 3-5 ng/ml) and extended-release tacrolimus (trough levels:3-5 ng/ml), in order to provide superior renal function…
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
A close correlation has been demonstrated between iron absorption and the capacity of gastric juice to release food iron. At high levels of gastric pH (>3,6), negligible amounts of non-haem iron would be released from dietary components and…
To confirm that loss of gut wall integrity is associated with the development of biliary atresia and to investigate possible hypoxia in the liver/bile ducts in children with biliary atresia using NIRS
Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
Objective: Primary objectives: To screen TCR/BCR repertoires in patients with primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC).Secondary objectives: To determine the influence of disease…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
To investigate the potential beneficial effect of increasing protein in the diet in order to decrease hepatic lipid accumulation on a high-fat diet.
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
To study the association between hypercoagulability and liver fibrosis.
Prevention of NAS will result in less retransplantations due to NAS. This in turn will result in a shorter waiting list with less morbidity and more important less mortality while waiting for a donor liver. Patients will also be less often…
To evaluate the prevalence of gastrointestinal ischemia in patients with acute and chronic non-cirrhotic, non-malignant PVT.
Primary objective:To assess the effects of fenretinide on hepatic and peripheral insulin sensitivity in obese, insulin resistant subjectsSecondary objective:To assess the effects of fenretinide on hepatic steatosis, body weight and body fat…