76 results
Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
Objective: Primary objectives: To screen TCR/BCR repertoires in patients with primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC).Secondary objectives: To determine the influence of disease…
To study the association between hypercoagulability and liver fibrosis.
The primary aim is to characterize mucosal immune responses in concomitant PSC and IBD. Secondary objectives are (1) to identify phenotype and function of the mucosal immune responses in peripheral blood, liver and intestinal biopsies of patients…
Primary objective: to investigate the incidence of IAC in patients resected for presumed PHC.Secundary objectives:- Evaluation of the diagnostic accuracy of histological criteria for IAC compared to IgG4 qPCR test- Evaluation of disease activity by…
The most important objectives of this study:1) examine the bacterial translocation as a consequence of elevated intestinal permeability in the morbid obese compared to controls, and to proove this is causes an inflammatory status predisposing IR/…
The aim of this study is to investigate the effect of ATP8B1 carrier on hearing in human.
To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.
Hypothetically, in patients with PBC or PSC the FGF-19 production or -response could be altered. The goal of this research is to study the FGF19 production after a standardized oral fat challenge and the effect of this FGF19 production on bile acid…
We want to evaluate the relation between intestinal integrity and the constitution of the intestinal microbiota, versus inflammatory and insulin resistance in patients with morbid obesity and patients with a normal weight.