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Reinforcement of closure of stoma site

To assess whether a biological mesh (collagen tissue matrix) reduces the incidence of clinically detectable stoma closure site hernias at two years compared to standard closure techniques.

Gum chewing to prevent postoperative ileus after abdominal surgery; A multi-centre randomised single- blinded study.

In the Netherlands, gum chewing has not been incorporated in the standard postoperative care after intra-abdominal surgery. Therefore a multi-center RCT was set up to evaluate the influence of gum chewing on the development of ileus. Our null…

Antecolic versus retrocolic route of the gastroenteric anastomosis after pancreatoduodenectomy: ARCO-trial

Primary objective:To determine the relationship of route of gastroenteric anastomosis after PD and postoperative incidence of DGE.Secondary objectives:To determine the relationship of route of gastroenteric anastomosis after PD and gastric emptying…

Comparing the effects of a new method to prevent constipation according to the usual method to prevent and to treat constipation bij patients lying in the hospital with a neurological disease.

The effectivity of a standard preventing constipation and treatment list, designed by the hospital nutritionteam, will show that neurological patients during their stay in the hospital develop less constipation.

Prevent Trial;Prevention of parastomal hernia during construction of a colostomy by reinforcing the bowel wall with a polypropylene mesh. ;A multicentre randomized controlled trial.

Patients in whom a permanent (end) colostomy is created in (semi) elective setting are randomised between the placement of a polypropylene mesh during stoma creation and the classic method without a mesh. Primary aim: Does the use of a lightweight…

A randomized clinical trial to evaluate the efficacy of polyethylene glycol vs psyllium fiber to prevent rebleeding in patients hospitalized with bleeding diverticular disease.

To evaluate the efficacy of laxatives (polyethylene glycol) versus supplementation of fibers on the incidence of rebleeding in patients hospitalized for colonic diverticular bleeding.

Clip Placement Following Colonic Endoscopic Mucosal Resection (EMR). The CLIPPER Study: A nationwide multicentre randomized clinical trial.

To investigate whether prophylactic clipping (PC) after endoscopic mucosal resection (EMR) of a flat polyp in the colon prevents delayed bleeding (DB) and is cost-effective.

Gluteal turnover flap for closure of the perineal wound after abdominoperineal resection for rectal cancer, BIOPEX 2-study

The high morbidity rate of the perineal wound has resulted in a continuing discussion on how to close the perineal defect after APR. Our research group recently published the BIOPEX-study (NL42094.018.12), in which 104 patients were randomized…

Prevention of incisional hernias with prophylactic synthetic mesh placement during stoma reversal

The aim of this study is therefore to prospectively investigate whether prophylactic synthetic mesh placement reduces the rate of stomal site incisional hernias after stoma closure without increasing (infectious) complications.

Effect of food additive E171 (titanium dioxide) on the development of colorectal cancer, an early biomarkers research.

In this intervention study, the primary aim is to evaluate the influence of E171 exposure on the gene expression profile in rectal biopsies. In addition, inflammatory markers such as ROS in the rectal epithelium will be measured as secondary outcome…