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Colonic motility distal to a deviating ileostomy after rectal resection and construction of a primary anastomosis

The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…

Prevention of septic complications in low anterior resection for rectal carcinoma: the role of Platelet Derived Growth Factors. A pilot study

To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.

Anorectal function and the effect of childbirth in patients with M Crohn

Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…

Perianal and anorectal complications in patients with inflammatory bowel disease in time

1.To prospectively evaluate the course of anorectal function in IBD patients with perianal lesions2.To establish potential biomarkers to predict the course of anorectal function in IBD patients with perianal lesions

Anorectal function and clinical symptoms in patients with a third degree anal sphincter rupture: longterm follow-up

- to establish the long-term alteration of anorectal function in women after promary repair of a third degree obstetrical anal sphincter rupture- to evalute the following complaints in women in late postpartum period after 3rd degree rupture:…

Simultaneous Integrated Boost Radiation Therapy with concomitant Capecitabine and Mitomycin-C chemotherapy for locally advanced Anal Carcinoma

Primary objective of the study is the assessment of the dose limiting toxicity (DLT) and the maximal tolerated dose (MTD) of capecitabine and mitomycin-C with concomitant SIBRT in patients with locally advanced anal carcinoma.Secondary objectives…

CyTOF and microbiota analysis on Crohn*s disease-associated and idiopathic perianal fistulas

To determine the differences in immune cell populations, microbiota and fibroblasts between fistulas from patients with and without Crohn*s disease.

Gluteal turnover flap for closure of the perineal wound after abdominoperineal resection for rectal cancer, BIOPEX 2-study

The high morbidity rate of the perineal wound has resulted in a continuing discussion on how to close the perineal defect after APR. Our research group recently published the BIOPEX-study (NL42094.018.12), in which 104 patients were randomized…