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Anorectal continence and defecation reflex tests: pilot study

1. To investigate whether we are able to initiate and measure the continence and defecation reflex in healthy human volunteers with our new method. 2. To compare the results of these measurements with those of existing techniques.3. To investigate…

Role of host cell DNA methylation analysis in predicting non-regression or regression of high-grade anal intraepithelial neoplasia in HIV+ men trial (MARINE)

In this study we clinically validate if host cell DNA methylation markers can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance and the safety of withholding treatment. This could prevent…

An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples in a first line setting from patients diagnosed with metastatic Colorectal Cancer (mCRC) to determine the KRAS G12C mutation status as part of the inclusion criteria into the Amgen Phase III clinical trial (Protocol No 20210081) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit, as a screening test in Amgen*s Phase 3 Clinical Study Protocol 20210081, in order to identify patients with mCRC KRAS G12C mutation positive tumors to be enrolled in the drug clinical trial. Results of…

Brain activation in fecal storage, defecation and fecal incontinence: an fMRI study in healthy volunteers, fecal incontinent patients and sacral neuromodulation

The purpose of the present study is the identification of brain areas and patterns involved in the sensory process of fecal urgency, and how these areas and patterns are influenced by sacral neuromodulation. We hypothesize that fecal incontinent…

Brain activation in fecal storage, defecation and fecal incontinence: a 1,5T fMRI pilot study in healthy volunteers

The purpose of the present study is to verify and optimize the quality of the MRI-images using balloon dilatation during a 1,5T fMRI-scan with a send/receive head-coil in healthy subjects in Maastricht University Medical Center.The primary aim of…