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A Phase III Randomized Open-Label Study of Single Agent Pembrolizumab vs. Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus that have Progressed after First-Line Standard Therapy (KEYNOTE-181)

Primary:1) To compare OS in subjects with squamous cell carcinoma of the Esophagus.2) To compare OS in subjects with PD-L1 Combined Positive Score (CPS)*10%3) To compare OS in all subjectsSecondary:1) To evaluate the progression free survival (PFS)…

Multicenter, randomised controlled trial comparing endoscopic Mucosal resection (EMR) And endoscopic submucosal dissecTIon (ESD) for resection of Large Distal non-pedunculated colorectal Adenomas

The aim of this study is to perform a randomized comparison between ESD and EMR in large (>20 mm) distal non-pedunculated polyps in a Western population. We aim to compare both procedures with regard to recurrence rates and radical (R0)…

Sirolimus for the treatment of severe intestinal polyposis in patients with familial adenomatous polyposis (FAP); a pilot study

The aim of our study is to investigate the effect of sirolimus on the progression of intestinal adenomas in patients with FAP and to assess the safety of this treatment.

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery II Study. A randomized clinical trial.

The primary objective of the study is to compare the ADR between PCSC and CC in patients referred for diagnostic, screening (non-iFOBT based) or surveillance colonoscopy.Secondary objectives are the following:- To compare the polyp detection rate (…

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

• Evaluate the safety of ME-APDS in subjects during colonoscopy.• Assess the efficacy of ME-APDS - whether the use of the ME-APDS improves the Adenoma Per Colonoscopy APC when compared to conventional colonoscopy (CC). Thereby we aim to further…

Into the light: guided visualization of high-risk cancer precursor lesions

Research directionUntil now only the tumor has been part of the search for new molecular imaging targets. The associated microbial biofilm that is present on 89% of right-sided CRCs and conventional advanced adenomas (CAAs) has so far not been…

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery I Study

The primary objective of this study is to evaluate the feasibility of the Pentax CADe-system during colonoscopy procedures in terms of the polyp detection rate (PDR). We hypothesize that the use of the Pentax CADe-system is feasible and enables…

Endoscopic Resection of Papillary Adenomas; a Novel Treatment Algorithm to Prevent Recurrence - a pilot-study

To assess the safety and feasibility of endoscopic papillectomy combined with thermal ablation of the biliary orifice by cystotome and STSC of the lateral resection margins.

A phase 2 intervention study:
Detection of early esophageal neopastic lesions by quantified fluorescence molecular endoscopy using oral and topical administration of bevacizumab-800CW and cetuximab-800CW

Primary objectives:The primary objectives are to evaluate the feasibility of oral administration of bevacizumab-800CW and cetuximab-800CW for detection of neoplasia in BE patients compared to HD-WLE to shorten the qFME procedure and test whether…

Synergistic effect of G-Eye balloon for behind the folds visualization with artificial intelligence assisted polyp detection (Discovery system) on adenoma detection rate.
*Discovery III study*

The primary objective of this study is to compare the effect on ADR of combining balloon-assisted and CADe assisted colonoscopy, compared to CADe assisted colonoscopy only.Secondary objectives are to compare the effect of adding balloon-assisted to…

A Phase 1b/2, Multicenter, Open-label Basket Study Evaluating the Safety and Efficacy of Bemarituzumab Monotherapy in Solid Tumors with FGFR2b Overexpression

This study has been transitioned to CTIS with ID 2023-505455-44-00 check the CTIS register for the current data. Part 1 (phase 1b)Primary:• To observe the safety and tolerability of bemarituzumabSecondary:• To evaluate preliminary antitumor activity…

Trans-Oral Sampling as an alternative Surveillance of Barrett*s Esophagus Pilot:
The TOSS pilot-study

to determine the number of sufficient quality samples obtained through the use of the Cytosponge, which could potentially serve as a substitute for endoscopic sampling.

Trans-Oral Sampling as an alternative for Barrett Surveillance: Transitioning Across Different Sampling Modalities through Cross-Validation; .

To evaluate the consistency and diagnostic accuracy of risk profiles using genetic markers across three different sampling modalities: biopsy, brush sampling, and TOS.

The European Polyp Surveillance study

1. To investigate the optimal time interval for colonoscopy surveillance in patients with low-risk and high-risk adenomas (EPoS I trial and EPoS II trial); 2. To evaluate the yield of surveillance in patients with clinically relevant serrated polyps…

PReoperative Optimisation of Modifiable rIsk factorS in surgEry of the Pancreas:
the implementation of best practice before pancreatic resection

To investigate whether implementation of a best practice program for preoperative optimisation of patients with a focus on screening, assessment, and intervention of 8 potentially (partly) modifiable risk factors (low (aerobic) fitness level,…

MAGENTIQ-COLO CSC study
Evaluation of the diagnostic performance of computer-aided polyp size classification of the MAGENTIQ-COLO during real-time colonoscopy

The primary objective of the study is to assess the diagnostic performance of the endoscopist performing a MAGENTIQ-COLO CADx-assisted colonoscopy to classify polyps as diminutive (<=5mm) or non-diminutive (>5mm) compared to size…