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A randomized controlled multicenter trial of a five day course of oral colistin and neomycin followed by restoration of the gut microbiota using fecal transplantation to eradicate intestinal carriage of extended spectrum beta-lactamase or carbapenemase-producing Enterobacteriaceae in high-risk patients

The purpose of this study is to evaluate the efficacy of two antibiotics ( neomycin sulfate and colistin sulfate), followed by fecal bacteria therapy , to multidrug - resistant bacteria (E - ESBL and EPC) to be eradicated from the intestine.

Intraoperative assessment of microcirculation with Laparoscopic Laser Speckle Analysis (lapLASCA) in patients elected for colorectal surgery for prediction of anastomotic leakage in colorectal anastomoses.

Experimentally, develop a software algorithm to objectively assess the microcirculation quality of the colorectal wall, intraoperative, by laparoscopy to predict the probability of developing anastomotic leakage, with the intention to develop a…

A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).;and substuy protocol:;A multi-center sub-study to validate the CDAD-DaySyms (Clostridium difficile-associated diarrhea - Daily Symptoms) PRO in sub CDAD participating in study AC-061A301 or AC-061A302.

Primary objectiveTo determine whether the clinical response after 10-day oral administration of cadazolid is non-inferior to oral vancomycin in subjects with CDAD.Secondary objectivesTo determine whether oral administration of cadazolid for 10 days…

Seroprevalence of hepatitis E virus infections among vegetarians.

In the present study we aim to test the hypothesis that the reservoir of HEV in the Netherlands are animals that are bred for meat consumption. Therefore we want to compare the HEV seroprevalence in vegetarians and in people with a very low meat/…