Search for a trial

A randomized controlled multicenter trial of a five day course of oral colistin and neomycin followed by restoration of the gut microbiota using fecal transplantation to eradicate intestinal carriage of extended spectrum beta-lactamase or carbapenemase-producing Enterobacteriaceae in high-risk patients

The purpose of this study is to evaluate the efficacy of two antibiotics ( neomycin sulfate and colistin sulfate), followed by fecal bacteria therapy , to multidrug - resistant bacteria (E - ESBL and EPC) to be eradicated from the intestine.

Intraoperative assessment of microcirculation with Laparoscopic Laser Speckle Analysis (lapLASCA) in patients elected for colorectal surgery for prediction of anastomotic leakage in colorectal anastomoses.

Experimentally, develop a software algorithm to objectively assess the microcirculation quality of the colorectal wall, intraoperative, by laparoscopy to predict the probability of developing anastomotic leakage, with the intention to develop a…

A multi-center, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).;and substuy protocol:;A multi-center sub-study to validate the CDAD-DaySyms (Clostridium difficile-associated diarrhea - Daily Symptoms) PRO in sub CDAD participating in study AC-061A301 or AC-061A302.

Primary objectiveTo determine whether the clinical response after 10-day oral administration of cadazolid is non-inferior to oral vancomycin in subjects with CDAD.Secondary objectivesTo determine whether oral administration of cadazolid for 10 days…

Transluminal Endoscopic step-up approach versus miNimally invasive SurgIcal step-up apprOach in patients with infected pancreatic Necrosis: TENSION, a randomized controlled parallel-group superiority multicenter trial. Dutch Pancreatitis Study Group.

To determine the effectiveness and, subsequently, the cost-effectiveness of a endoscopic transluminal step-up approach (ETD & ETN) versus a surgical step-up approach (PCD & VARD ,if not possible laparotomy) to improve clinical…

Effect of Galacto-Oligosaccharides supplementation on amoxicillin-treated gut microbiota from healthy adults : a proof of principal study

To explore whether the promising effects of GOS supplementation on the composition and activity of gut microbiota from healthy adults as found by in-vitro, can also be observed in-vivo.

Seroprevalence of hepatitis E virus infections among vegetarians.

In the present study we aim to test the hypothesis that the reservoir of HEV in the Netherlands are animals that are bred for meat consumption. Therefore we want to compare the HEV seroprevalence in vegetarians and in people with a very low meat/…

Antibiotic treatment alone for children with acute appendicitis; a prospective cohort study part of the Antibiotic versus Primary Appendectomy for Children with acute appendicitis; the APAC trial.

1. What is the complication rate of the initial antibiotic treatment strategy for acute simple appendicitis (radiological proven) in children aged 7-17 years old?

Novel therapies for secretory diarrhea

This study aims to assess the efficacy and potency of newly developed small molecule inhibitors of the GC-C signaling pathway and of the CFTR chloride channel in native human intestinal tissue.

Ammonia detection in Helicobacter pylori infections with the Ammonia Breath Analyzer (ABA) demonstrator. A pilot study to investigate the clinical application of the ABA.

The aim of this study is to assess the change of ammonia exhaled in Helicobacter pylori (HP) positive patients compared with patients that are not HP infected after urea administration. In principle, in this pilot study, the results of Kearney et al…

STAT Trial: Stoma or Intestinal Anastomosis for Necrotizing Enterocolitis of the Neonate: Multicentre Randomized Controlled Trial

The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.

MR imaging of acute appendicitis in adults

Primary Objective: To determine the sensitivity and specificity of MRI in a consecutive series of adult patients suspected for acute appendicitisSecondary Objective(s): Is MRI of additional value in adult patients with inconclusive US? And is…

Prevalence of Tropheryma whipplei in duodenum and colon, using real-time PCR

To determine the prevalence of T. whipplei in duodenum and colon in a random population of patients whom will undergo an endoscopy at the VUmc

MR Imaging of acute appendicitis in children

To determine the value of MRI in a consecutive series of pediatric patients suspected for acute appendicitis

Treatment of recurrent Clostridium difficile infection with fecal therapy:
the FECAL trial (Fecal enema to Eliminate Clostridium difficile Associated Longstanding diarrhea)

With this study we will investiagate the superiority of fecal clysma therapy (n=34 patients) above conventional therapy with the antibiotic vancomycin (n=34 patients) or bowellavage with conventional antibiotic therapy (n=34 patients).

Efficacy and Safety of Quadruple Therapy by Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Given x 10 days With Omeprazole in Eradication of Helicobacter pylori: A Comparison to Omeprazole, Amoxicillin and Clarithromycin Given x 7 days

The goal of this trial is to confirm that eradication rates obtained with Pylera are compatible to those obtained with the current European gols standard, OAC 7 days. This trial will constitute a pivotal trial leading eventually to approval of…

Study of susceptibility to bacterial gastroenteritis

In case of food- or water related outbreaks of bacterial gastroenteritis, the regular research of Municipal Health Services (GGD) and the Food and Consumer Product Safety Authority (VWA) aims at control of the outbreak.The aim of this project is to…

Post travel screening
Screening for relevant parasitic infections in asymptomatic travellers returning from the tropics

To determine the usefulness of multiplex real-time pcr to detect asymptomatic parasitic infections in travellers returning from the tropics.

*The use of fecal calprotectin in detecting immunotherapy induced colitis and feasibility for the use of immunohistochemical markers in patients receiving checkpoint inhibitors*- a pilot study

Primary: To determine fecal calprotectin in patients treated with checkpoint inhibitors. Secondary: To describe endoscopic and histologic findings in patients with symptoms that may indicate colitis.To study cytokine production profiles of the…

Double-blind, randomized, placebo-controlled, phase III trial on the efficacy and tolerability of a 6-week treatment with budesonide effervescent tablets vs. placebo for induction of clinico-pathological remission in adult patients with active eosinophilic esophagitis

Primary:* To assess the efficacy of 2 x 1 mg/d budesonide effervescent tablets vs. placebo for the induction of clinico-pathological remission in adult patients with active eosinophilic esophagitis (EoE).Secondary:* To study safety and tolerability…

Modified Exclusive Enteral Nutrition with the Crohn's Disease Exclusion Diet for Induction and Maintenance of Remission and Re-biosis

To prove that sustained clinical remission can be maintained at week 14 with a new dietary strategy that involves only 2 weeks of EEN with Modulen and 22 weeks of an exclusion diet involving selected table foods. We hypothesize that use of EEN for…