150 results
PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…
To assess the long-term safety, efficacy, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) when administered orally for 36 weeks in paediatric subjects with functional constipation. Evaluation of lubiprostone…
To test the hypothesis that salivary pepsin is able to predict outcome of treatment in GERD suspected infants.
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…
To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…
The aim of the study is to investigate and understand the performance of three new baseplates consisting of a neutralizing layer and one of three adhesives (two new adhesives and one known adhesive) in terms of protecting the skin from damage…
Investigate if an increased consumption of VITACEL Wheat Fiber can enhance fecal bulk. Furthermore, we want to demonstrate that the increased consumption of wheat fiber can increase stool frequency and consistency.
Main questions:1. What is the success rate of antireflux surgery in children (reflux control) measured by means of validated and standardised investigation techniques?2. What is the effect of antireflux surgery on gastro-esophageal motility/function…
To determine the (cost-)effectiveness and budget impact EM-guided bedside placement as compared to endoscopic placement of a nasoenteral feeding tube in surgical patients.
Primary Objective: To assess the impact of RYGB on gallbladder function (during a follow-up interval of 1 year). We will assess the fasting volume, the ejection fraction and the residual volume of the gallbladder. In addition, we will compare serum…
Therefore, the aim of this study is to determine normal-values for esophageal pressure characteristics using a water-perfused high-resolution manometry catheter. Furthermore, we aim to compare pres
To compare the efficacy of a fixed dose of SC methylnaltrexone to induce laxation in patients receiving palliative care with constipation due to either fentanyl, oxycodone or morphine sulphate (opioids with different mechanisms of action). Secondary…
Identification of the underlying genes of MMIHS
The objective of this study is to determine user perception of the 2-piece flat skin barrier compared to the current Dansac flat 2-piece barrier, specifically as it relates to barrier adhesion, barrier tack, comfort, leakage, and ease of barrier…
This study has two main objectives:1. To assess the efficacy of hypnotherapy on symptoms and quality of life in IBS patients;2. To compare the efficacy of individual hypnotherapy with a group application of hypnotherapy in IBS treatment.
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…
The aim of this project is to study the effect of nicotine gum chewing in the prevention or reduction of POI and reduction of opioid use on patients who underwent elective colorectal surgery, and evaluate its safety and possible adverse effects.
To assess the efficacy, safety, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) (based on subject body weight at baseline) as compared to matching placebo BID, when administered orally for 12 weeks in…
To evaluate the safety and efficacy of long term stimulation of the lower esophageal sphincter in patients with gastroesophageal reflux disease after sleeve gastrectomy.
The objective of this clinical trial is to evaluate the tolerance and effectiveness of 4 week supplementation of a proprietary polydextrose fiber product, in a dose-ranging fashion, on whole gut transit time and gastrointestinal symptoms in adults…