40 results
To assess the long-term safety, efficacy, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) when administered orally for 36 weeks in paediatric subjects with functional constipation. Evaluation of lubiprostone…
The aim of the study is to investigate and understand the performance of three new baseplates consisting of a neutralizing layer and one of three adhesives (two new adhesives and one known adhesive) in terms of protecting the skin from damage…
To determine the (cost-)effectiveness and budget impact EM-guided bedside placement as compared to endoscopic placement of a nasoenteral feeding tube in surgical patients.
To compare the efficacy of a fixed dose of SC methylnaltrexone to induce laxation in patients receiving palliative care with constipation due to either fentanyl, oxycodone or morphine sulphate (opioids with different mechanisms of action). Secondary…
This study has two main objectives:1. To assess the efficacy of hypnotherapy on symptoms and quality of life in IBS patients;2. To compare the efficacy of individual hypnotherapy with a group application of hypnotherapy in IBS treatment.
To evaluate the safety and efficacy of long term stimulation of the lower esophageal sphincter in patients with gastroesophageal reflux disease after sleeve gastrectomy.
Hypotheses1) The use of a combination of probiotic strains results in a significant increase in defecation frequency in pregnant women with constipation.2) The use of a combination of probiotic strains results in less episodes of difficult…
The aim of this study is to assess the number of supragastric belches and reflux episodes before and after speech therapy in GERD patients with troublesome belching symptoms due to an increased number of supragastric belches.
In this study we aim to determine the esophageal sensitivity by means of weakly acidic solution and esophageal distension, and determine the position and composition of the acid pocket in patients with and without PPI. We hypothesize that these…
Earlier studies suggest that Gaviscon alters the position of the acid pocket, as the number of acid reflux episodes decreased but the number of nonacid reflux events almost doubled after drug intake. (8) However, until now the formation of the raft…
The primary safety objective of this investigation is to assess the safety of long-term LES electrical stimulation therapy in patients with GERD.The primary functionality objective of this study is to evaluate the ability of the device to initiate…
The aim of this study is to gain insight in the mechanisms that may be involved in the effects of plant sterol drinks on gastric emptying and gallbladder motility. In order to test this, we compare the different effects of the consumption of a plant…
The objective of this study is to assess the technical feasibility of the EsoFLIP dilation balloon in the treatment of achalasia
To assess the effect of amitriptyline on gastro-esophageal symptom severity and on esophageal sensitivity to acid perfusion and balloon distension in patients with documented functional heartburn.
To compare the efficacy of POEM to the efficacy of endoscopic pneumodilatation as the initial treatment of symptomatic idiopathic achalasia. The treatment succes is defined as symptom relief based on a Eckhardt score of 3 or less at 3 months, 1 year…
The aim of the study is to assess the cost-effectiveness of implementation of tube feeding in hospitalized IBD patients.
Aim: Is the Bifidobacterium breve effective in the treatment of childhood constipation.
the aim of the current pilot investigation is to examine the effectiveness of mindfulness based stress reduction in reducing stress levels in IBS patients, as well as the effects of the training on IBS symptom severity and quality of life in these…
The primary objective of this study is to assess the effect of band placement and of different stages of band adjustment on the esophageal bolus transit time and clearance by using intra-esophageal high resolution manometry and impedance monitoring…
The primary aim of this study is to assess the effect of weight loss in obese subjects, brought about by non-surgical methods, on all types of gastroesophageal reflux (gaseous, liquid and mixed, acid and nonacid), as measured by ambulatory pH/…