26 results
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…
The first objective is to assess the value of colonoscopy screening in HL survivors. The second objectives are to evaluate the neoplasia characteristics and its relation to radiotherapy and chemotherapy, in order to improve the understanding of the…
To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.
To directly evaluate the gastric tube microcirculation with Dark Sidestream imaging during minimal invasive esophageal resection on several locations, i.e. from best arterial blood supply (antrum) to worst (fundus). Furthermore, to evaluate the…
Primary Objective(s): In this study we try to unravel the behavior of stem cells in relation to their (stromal) niche, genetic mutations, altered RNA expression and expression of tumor markers in serum for better prognostication of pancreatic…
1) To investigate what changes are present in skeletal muscle tissue of elderly gastric and colonic cancer patients (>80) compared with younger gastric and colonic cancer patients (<60) and compared to elderly controls and younger…
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
To investigate whether local inflammation in the area of the stomach and gastroenteric anastomosis is a cause of primary DGE.
Hypothesis.In women with preeclampsia endovascular remodeling and invasion of the spiral arteries is less prominent which will result in overwhelming placental oxidative stress and pregnancy failure. Abnormal function of trophoblast and stroma cells…
The purpose of this project is to determine and analyze miRNA expression profiles from freshly frozen human colon tissue as well colorectal adenomas and carcinomas to identify specific miRNAs or miRNA clusters whose expression is altered in…
Is is possible to detect tumorcells in blood in patients with colon cancer with RT-q-PCR.
1) to sample ACF in colorectal mucosa of patients without an increased risk of CRC, patients at an increased of recurrent advanced adenoma based on a personal history of adenomas, patients with established CRC and patients with HNPCC and to…
To determine which DC populations are present in esophageal tissue of patients with reflux esophagitis and BE. Relate the findings regarding DC populations to other pre-malignant gastrointestinal disorders (IBD).
Primary objective:To determine the relative risk of gastric cancer for genetic polymorphisms.Secondary objectives:- To determine the relative risk of gastric cancer for combinations of genetic polymorphisms, H. pylori virulence factors and lifestyle…
Primary Objectives:1. To compare the protein synthesis of pancreatic, liver, intestinal, fat and muscle tissue and leukocytes in cachectic patients.2. To compare pancreatic malignancy protein synthesis with the protein synthesis in normal pancreatic…
Primary Objective: The primary objective is to study the potential role of F. nucleatum in the development of colorectal cancer by isolating F. nucleatum strains from large adenoma biopsies, healthy colorectal tissue and matching stool and saliva…
Primary Objectives:1. To compare protein synthesis rate of the tumour and normal pancreas between cachectic and non-cachectic patients with pancreatic cancer.Secondary Objective(s):1. To compare protein synthesis rate of liver, intestinal, adipose…
The primary objective of this study is the simultaneous characterization of human and microbiota genomic and transcriptomic components in healthy and adenoma mucosal samples as well as stool and saliva. In addition, microbiome shifts from normal…