37 results
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
Allogeneic hematopoietic stem cell transplantation is often complicated by graft versus host disease (GvHD) causing high morbidity and mortality. Loss of gutmicrobial diversity is a risk factor to develop GvHD. We will test the hypothesis that…
The first objective is to assess the value of colonoscopy screening in HL survivors. The second objectives are to evaluate the neoplasia characteristics and its relation to radiotherapy and chemotherapy, in order to improve the understanding of the…
To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.
To directly evaluate the gastric tube microcirculation with Dark Sidestream imaging during minimal invasive esophageal resection on several locations, i.e. from best arterial blood supply (antrum) to worst (fundus). Furthermore, to evaluate the…
Primary Objective(s): In this study we try to unravel the behavior of stem cells in relation to their (stromal) niche, genetic mutations, altered RNA expression and expression of tumor markers in serum for better prognostication of pancreatic…
This study will contribute to improving quality of care for cancer survivors, since sexual problems seem to be profound but not always discussed with patients. Patients are now often insufficiently informed and do not know how to interpret their…
The aim of this study is to determine the patients* and endoscopists experiences and patients* safety with different sedation protocols.
The aim of this study is to evaluate an intervention aimed at improving family disclosure of inherited cancer risks by 1) supporting counselees in what they experience as a necessary, but at times difficult, task and, consequently 2) provide more at…
1) To investigate what changes are present in skeletal muscle tissue of elderly gastric and colonic cancer patients (>80) compared with younger gastric and colonic cancer patients (<60) and compared to elderly controls and younger…
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
To investigate whether local inflammation in the area of the stomach and gastroenteric anastomosis is a cause of primary DGE.
1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…
Study goal is to answer the following question:Is there an effect of interactive education with a web-application on patient satisfaction for patients undergoing a colonic resection?Sub-questions are:1. Do patients with a higher education level have…
The primary objective of this study is to evaluate the prevalence and risk of advanced colorectal neoplasia in asymptomatic non-PSC post-liver transplant recipients compared to an age- and sex matched general population.Secondary Objectives- To…
Hypothesis.In women with preeclampsia endovascular remodeling and invasion of the spiral arteries is less prominent which will result in overwhelming placental oxidative stress and pregnancy failure. Abnormal function of trophoblast and stroma cells…
The purpose of this project is to determine and analyze miRNA expression profiles from freshly frozen human colon tissue as well colorectal adenomas and carcinomas to identify specific miRNAs or miRNA clusters whose expression is altered in…
Is is possible to detect tumorcells in blood in patients with colon cancer with RT-q-PCR.
1) to sample ACF in colorectal mucosa of patients without an increased risk of CRC, patients at an increased of recurrent advanced adenoma based on a personal history of adenomas, patients with established CRC and patients with HNPCC and to…