145 results
Primary objective:The objective of this randomized phase 2 study is to demonstrate efficacy of RE in terms of PFS in colorectal cancer patients with liver-only metastases who are candidates for palliative systemic treatment with capecitabine plus…
The aim of this study will be to evaluate the applicability of using CCE in the Dutch colorectal cancer screening programme in participants with positive FIT outcomes who have contra-indications for subsequent colonoscopy, who have a prior…
Primary:To evaluate the performance of FME with topical administration of Bevacizumab-800CW for detection of neoplasia in BE patients compared to HD-WLE to make an estimation of the diagnostic accuracy in terms of sensitivity and specificity in…
The aim of this study is to assess the performance of our CADe/CADx system in detecting and diagnosing Barrett neoplasia during live endoscopic procedures.
This study has been transitioned to CTIS with ID 2023-510481-27-00 check the CTIS register for the current data. This study evaluates the yield of NIR-Fluorescence imaging as additional surgical-tool for visualization and assessment of local extent…
Primary:Sub-study I:- To develop high-quality fast quantitative MRI protocol for multi-contrast imaging of tumour pathophysiology at 3T in esophageal cancer patientsSub-study II:- To determine inter- & intra-session test-retest…
- To assess the feasibility, safety and tolerability of cRGD-ZW800-1 for visualization of (neoadjuvantly treated) pancreatic carcinomas, perihilar or distal cholangiocarcinomas and if present associated metastatic lymph nodes and their distant…
Evaluating the feasibility of 18F-Fluciclatide PET/CT imaging of colorectal and pancreatic tumors.
Primary objective: to investigate how many patients with detectable ctDNA after surgery start with adjuvant chemotherapySecondary objective: to reduce recurrence rate by ctDNA based adjuvant chemotherapy (ACT) in stage II colon cancer (CC) patients…
The objective of this study is to pilot the feasibility of MRI and cine imaging in improving pre-operative staging of colon tumors. The specific aims of this pilot study are to establish an optimized scanning protocol and provide preliminary…
To assess whether ctDNA can be detected in PLF using the mFAST-SeqS method in a prospective cohort of patients with GC/GEJC who undergo a DLS.
This study has been transitioned to CTIS with ID 2024-517258-85-00 check the CTIS register for the current data. The primary objective of this study is to determine the feasibility and safety of quantitative fluorescence endoscopy using the…
Primary Objective: The primary objective of this study is to implement a patient-led home-based follow-up approach in patients treated surgically for CRC. A successful implementation of the patient-led aspect is defined as 75% or less of optional…
Primary Objective: Exploring peri-operative changes in microbiota composition between patient receiving oral antibiotics, oral antibiotics with amphotericin B or no oral prophylaxis, performed by 16S rRNA sequencing, analyzed by Microbiome Center…
The primary outcome of this study is the detection of clinical relevant adenomas (>= 5mm) in the ileal pouch.
The primary outcome parameters are identification rate of SLN(s) or lymph node metastases with bevacizumab-800CW, defined as the number of patients in which a SLN or lymph node metastasis was detected due to fluorescence during surgery and/or…
We aim to study the rate of developing a biopsy-based diagnosis of high-grade dysplasia (HGD) and EAC in BE patients in a prospective cohort of 204 BE patients at high risk of progression (i.e. after endoscopic removal of visible lesions containing…
Primary Objective:- To compare adenoma detection rate (ADR) with versus without real-time automated detection (CAD EYE, Fujifilm)Secondary Objectives:- To compare the size, morphology and histology of adenomas detected and resected in both arms of…
Identification of patients with a high risk of progression of premalignant gastric lesions, in order to compose guidelines for surveillance and follow up.
This study has been transitioned to CTIS with ID 2024-510769-41-00 check the CTIS register for the current data. The main objective is to investigate the feasibility of a tumour-targeted fluorescent tracer SGM-101, combined with the use of the CE-…