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HYPerbaric OXygen therapy for benign anastomotIC esophageal strictures: a pilot study

The overall objective of this pilot study is to evaluate the effect of HBOT on recurrent and refractory esophageal anastomotic strictures.

Biodegradable self-expandable stents for pancreatic duct strictures due to chronic pancreatitis

The aim of this study is to investigate the safety and efficacy of biodegradable self-expandable stents in patients with a benign fibrotic pancreatic duct stricture due to chronic pancreatitis.

The role of intestinal fatty acid binding protein (iFABP) in the treatment of small bowel obstruction

usefulness of I-FABP in the surgical managment of small bowel obstruction caused by adhesions.

A RANDOMIZED COMPARISON OF DEGRADABLE ESOPHAGEAL STENT VS DILATION THERAPY: *DESTINY TRIAL* FOR PATIENTS WITH RECURRENT BENIGN ESOPHAGEAL STRICTURES

To compare the efficacy and safety of dilation of recurrent benign esophageal strictures by using a degradable self-expanding stent or standard dilation therapy.

Per-oral endoscopic submucosal myotomy (POEM) for treatment of achalasia: International multi-center trial

Primary Objective: • To evaluate treatment success, defined as successful symptom relief based on an Eckhard score <=3. Secondary Objectives: • Safety standards, defined as a rate of serious adverse events <2%. SAE are defined as death…

Clinical investigation of the safety of ALIMAXX-B biliary stent for bile duct obstruction

The primary objective of the study is to demonstrate safety and efficacy of the ALIMAXX-B* covered biliary stent.The secondary objective of the study is to evaluate technical success of stent placement, , re-interventions and time to occlusion.

Endoscopic Stenting versus Operative Intervention in Malignant Gastric Outlet Obstruction(STENTOP), a multi-center randomized controlled trial.

To investigate which treatment modality is preferable in patients with an irresectable malignant gastric outlet obstruction: endoscopic stent placement or a surgical gastrojejunostomy.

A randomized comparison of a fully covered self expandable metal stent versus a partially covered self expandable metal stent in malignant esophageal strictures

To compare a fully covered metal stent versus a partially covered metal stent in patients with dysphagia due to an incurable malignant stenosis of the esophagus or cardia.

A multicenter, double blind placebo-controlled randomised trial for benign esophageal anastomotic strictures: Savary dilation vs savary dilation with triamcinolon

To compare Savary dilation with saline 0.9% injections (placebo) with Savary dilation with triamcinolon injections in patients with benign anastomotic esophageal strictures

A Multi-Center, Prospective, Randomized Study Comparing Removable, Self-Expanding Metal Stents to Plastic Stents for the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis

To compare the use of Self Expanding Metal Stents (SEMS) to plastic stents for the treatment of benign biliary strictures secondary to chronic pancreatitis as it pertains to stricture resolution rates, complication rates and number of ERCP…

A 12-week, randomised, double-blind, placebo-controlled trial to evaluate the efficacy, quality of life, safety and tolerability of prucalopride in male subjects with chronic constipation.

Primary: To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.Secondary: To evaluate the safety, tolerability, effect on quality of life and effect on symptoms of prucalopride…

Endoscopic Balloon Dilatation of stenotic ileocecal anastomosis in Crohn*s disease with or without additive local steroid injection and oral Budenofalk* a double-blind, randomized, parallel group trial

The primary objective of this study is to evaluate whether adding intensive local anti-inflammatory therapy (Triamcinolone injection therapy combined with 9 mg oral BudenoFalk once daily for 24 weeks) to routine enteric balloon dilatation reduces…

Covered self-expandable metal stents for benign biliary strictures: a prospective multicenter trial

The aim of this study is to determine safety, patency of placement and long term symptom-free outcome of a covered self expandable metal stent in patients with a benign CBD stricture.

Plastic or Metal Stents for Primary or Recurrent Inoperable Malignant Extrahepatic Biliary Obstruction

To define indications for recently developed, but more expensive, self-expanding metal stents (SEMS) versus cheaper plastic stents in patients with primary or recurrent inoperable malignant extrahepatic common bile duct (CBD) obstruction, based on…

Unravelling the aetiology of pyloric stenosis; a role for the COL3A1 gene?

The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…

Assessment of trans-intestinal cholesterol excretion in patients with total biliary obstruction
(TICE-PTC)

To establish the presence of direct trans-intestinal cholesterol excretion (TICE) in humans by faecal recovery of i.v. administered 13C-cholesterol in patients with a total biliary obstruction. This is a so-called proof-of-concept study.

Sensitivity of cholangioscopy directed biopsies versus brush cytology in patients with malignant bileduct stenosis

Aim of this study is to assess the value of cholangioscopic directed biopsies versus brush cytology in differentiating between malignant and benign biliary strictures. Determination of tumor markers to improve early diagnosis of malignant biliary…

A new design metal stent, SX-Ella stent Esophageal HV, for the prevention of recurrent dysphagia due to migration or tissue overgrowth: a prospective follow-up study

To evaluate recurrent dysphagia, due to tissue overgrowth or migration, of the SX-Ella stent Esophageal HV in patients with dysphagia from inoperable carcinoma of the distal esophagus or cardia.

Phase III multicentre, Randomised, Double Blind, Comparative study to assess the efficacy and safety of lanreotide 30mg versus placebo as a palliative treatment of clinical symptoms associated with intestinal obstruction due to peritoneal carcinomatosis in inoperable patients

Primary objective:The primary objective of this study is to assess the efficacy of lanreotide 30 mg as compared to placebo to relieve clinical symptoms due to small bowel obstruction in inoperable patients with peritoneal carcinomatosis.Secondary…

A Multi-Center, Prospective Study of the Wall Flex ® RX Biliary Fully Covered Stent for the Treatment of Benign Biliary strictures

Primary Objective: To assess the safety and performance of temporary placement of the Wall Flex Biliary RX as a Fully Covered Stent Treatment of Biliary obstruction that result from benign bile duct strictures.