27 results
To assess whether changes in insulin sensitivity through dietary interventions affect postprandial bile acid metabolism and kinetics. Secondary objective: to assess TGR5 and FXR mediated pathways in insulin resistant and insulin sensitive states.
The primary objective of CDfuture is to provide duodenal biopsies of patients with and without CD, and venous blood samples, to continue CD research as described above.
The knowledge on PPI induced hypomagnesemia is restricted. For that reason, this study has two key objectives which investigate on the frequency and the causes of PPI induced hypomagnesemia:1. The investigation of the prevalence of PPI induced…
We propose to perform a pilot study to examine the feasibility of studying the triangular association between: 1) amino acid metabolism (influenced by, amongst other factors, diet composition [e.g. energy intake, macronutrient intake, individual…
Objective: The primary objective is to determine if the dietary fructan-fiber inulin is applicable in PPIH. More specific, it aims to (i) improve the magnesium balance in cases of hypomagnesemic PPI users and (ii) to evaluate if the use of inulin is…
To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls
The objective of this study is to assess the association of genetic polymorphisms known to be involved in coeliac disease with specific clinical phenotypes in coeliac disease.
The primary oblective of the study is to elucidate all molecular mechanisms leading to coeliac disease.In order to establish the scientific basis for the development of improved diagnostics, novel therapies and safer foods for patients, in the CDC:…
The aim of this study is to investigate the effect of two distalisation techniques of a gastric bypass in revisional surgery with standardised limb lengths in total weight loss (TWL) and the need for treatment for protein calorie malnutrition (PCM…
1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).
To quantitate the difference in digestion and absorption kinetics of dietary whole protein versus free amino acids in vivo in patients admitted to the ICU suffering from malabsorption.
To investigate whether adjusting the length of the BP-limb of the OAGB based on measured total small bowel length leads to more weight loss, resolution of co-morbidities with less development of micronutrient deficiencies and bowel movements…
This study has been transitioned to CTIS with ID 2024-519078-38-00 check the CTIS register for the current data. 1) To evaluate the efficacy and safety of the standard clinical care at the AMC in this patient population by the clinical outcomes (…
Primary Objective: Determining the prevalence in advanced-stage PD patients of increased bacterial TDC activity in faeces and the prevalence of increased AADC activity in serum.Secondary Objectives:- Correlating TDC activity and AADC activity to…
5.1 Primary ObjectiveTo confirm the efficacy of glepaglutide in reducing PS volume in SBS patients.5.2 Secondary ObjectivesTo evaluate the efficacy of glepaglutide on other efficacy endpoints in patients with SBS.To evaluate the safety and…
Primary Objective: Proof of safety and tolerability of home parenteral nutrition (HPN) with an Omega-3 fatty acid enriched MCT/LCT lipid emulsion in adult patients with chronic intestinal failure (CIF) in need of long-term HPNSecondary Objectives:…
This study has been transitioned to CTIS with ID 2024-513374-22-00 check the CTIS register for the current data. 5.1 Primary ObjectiveTo evaluate the long-term safety of glepaglutide treatment in SBS patients.5.2 Secondary ObjectivesTo evaluate the…
The main objective is to unravel the consequences of obesity treatment on women*s longer-term health, with a primary focus on musculoskeletal health (muscle mass and bone mineral density). Transgenerational consequences of obesity treatment on…
The purpose of this project is to provide a rational basis for the selection of small-molecule inhibitors that block the signalling of all cytokines involved in type I enteropathy-associated T cell lymphoma (type I EATL).
To study the effect of oral/enteral fructose on enterocyte function and on the the gut microbiome and intestinal absorption capacity in patients with short bowel syndrome who are dependent on parenteral nutrition (PN) and/or intravenous (iv) fluids.