99 results
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
The objective of this study is to identify direct or indirect pruritogens accumulating during cholestasis and to analyze the involved neuronal signaling pathways leading to the sensation of itch.
The aim of this study is to evaluate patients and surgeons aesthetic satisfaction and to assess the impact on self-esteem with immediate breast reconstruction using DIEP- flap procedure.
The objective is to determine if, and if so to what extend, there is a change in expressionpattern for hypoxic en proliferative markers.
The overall aim of this study is to examine, in adult female CCS in the Netherlands, the effects of treatment in general, and the effects of different types of treatment, doses of drugs, radiation sites and doses, and age at time of treatment, on: 1…
The goal of this study is to test the greater efficacy of the *COME ON, move on!* program in children, who received medical treatment for cancer, compared to pediatric physical therapy treatments without intensive coaching by Internet. This new…
To study the spread of STI among heterosexual males and females (heterosexuals) in Amsterdam in order to provide information for building evidence-based prevention strategies and to evaluate existing control programs. Three substudies are part of…
Our purpose is to establish whether the frequently observed absence of tumor regression in the presence of infiltrating T lymphocytes is due to a lack of T cell effector function or due to an inhibitory influence of the tumor microenvironment on T…
Beschrijven van het beloop van de kwaliteit van leven bij patiënten met kanker in samenhang met ziektecognities en copingstijl. Onderzoeken welke determinanten de ervaren kwaliteit van leven (mede) bepalen.
The primary objective of the present study is to obtain insight into the long-term effects of EC and new treatment strategies on HRQL in a population-based setting. Therefore, we will assess HRQL among 2 to 9 year survivors of stage I or II EC…
The objective of this study is to measure quality of life, health care use and morbidity (like fatigue, anxiety and depression) of patients diagnosed at least 2 years ago. These variables will be compared between the different treatment modalities…
To study motivational and psychological aspects, aestetic outcome, and general satisfaction in two groups of women who opt for mastectomy with breast reconstruction either with autologous material using the DIEP-flap procedure or with silicon…
With this information we hope to be able provide ex-patients with more detailed information about late effects of treatment. Also it is a very important step towards ajusting current treatment protocol to prevent late effects as much as possible.
To develop a non-invasive MR method to measure the local changes in glucose metabolism of human brain tumour, in order to answer to the question:Is the tumour glucose metabolism anaerobic?
To evaluate the effect of HSP90 inhibition by AUY922 on VEGF by means of 89Zr-bevacizumab PET. Primary endpoint: measurement of decreased VEGF compared to baseline. A decline is defined as a decrease of at least 30% in mean Standardized Uptake Value…
To evaluate the feasibility to assess treatment response on radiochemotherapy for locally advanced rectal cancer by repeated anatomical and functional MRI and FDG-PET.
To show the effect of the HSP90 inhibitor AUY922 on HER2 expression by means of 89Zr-trastuzumab PET scanning. Primary endpoint: measurement of decreased HER2 expression compared to baseline. A decline is defined as a decrease of at least 30% in…
The main objective of the study is to monitor the factors effecting success of PDT, namely oxygen, photosensitizer concentration and, light dose before and during illumination to gather data that can be clinically correlated and later implemented.
The main goal of this study is to obtain MRI scans for investigating new algorithms for improvement and acceleration of patient model generation for radiotherapy and hyperthermia treatment planning.