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Identification of novel childhood osteosarcoma predisposing genes.

To identify novel childhood osteosarcoma predisposing genes.

OPEN-LABEL, MULTI-CENTER, SINGLE-ARM STUDY FOR THE SAFETY AND EFFICACY OF
POMALIDOMIDE (CC-4047) MONOTHERAPY FOR SUBJECTS WITH REFRACTORY OR RELAPSED AND REFRACTORY MULTIPLE MYELOMA. A COMPANION STUDY FOR CLINICAL TRIALCC-4047-MM-003.

The primary objective is:To evaluate the efficacy of pomalidomide (CC-4047) monotherapy in subjects with refractory orrelapsed and refractory multiple myeloma who discontinued treatment after being treated withdexamethasone alone (Treatment Arm B)…

Role of oncogenes in chromosome region 17p11.2-p12 in osteosarcoma tumorigenesis

The purpose of this investigation is identify thecausative oncogenes in 17p11.2-p12, to clarify the mechanism of their amplification, and to determine their diagnostic and prognostic importance for patients with osteosarcoma.

T and NK cell mediated immunotherapy in Ewing's sarcoma (P03.040 amended version of December 2006)

We hypothesize that NK and/or T cell-mediated immunotherapy may represent a novel therapeutic option for patients with refractory and/or metastatic ES. Therefore, we will study molecular mechanisms that determine the susceptibility of ES to T and NK…

T and NK cell mediated immunotherapy in osteosarcoma; a preclinical feasibility study

We hypothesize that NK and/or T cell-mediated immunotherapy may represent a novel therapeutic option for patients with refractory and/or metastatic OS. Therefore, we will study molecular mechanisms that determine the susceptibility of osteosarcomas…

Gait symmetry of patients with an endoprosthetic reconstruction of the knee joint after bone tumour resection.

The primary goal of this study is to describe possible causes of gait asymmetry in patients with an endoprosthetic reconstruction of the knee joint due to a bone tumour. Therefore, the assumed gait asymmetry is first verified (part A). Subsequently…

A phase 2, single arm, European multi-center trial evaluating the efficacy of afatinib as first-line or later-line treatment in advanced chordoma.

Primary objectives- To evaluate the treatment efficacy by progression free survival (PFS) according to RECIST 1.1. - Quality of life assessmentSecondary objectives- To evaluate the treatment efficacy by growth modulation index- To evaluate the…

Long-term Follow-up Study for Participants Previously Treated with Ciltacabtagene Autoleucel

This study has been transitioned to CTIS with ID 2023-505530-10-00 check the CTIS register for the current data. The purpose of this long-term follow-up study is to monitor the health status of patients who were previously enrolled in cilta-cel…

Defining optimal imaging strategies for diagnosis, treatment, and treatment evaluation of chordomas and chondrosarcomas of the axial skeleton

Show that functional MR tumor plasma volume parameters Vp,max and Vp,mean change significantly within 1-6months following start of proton beam radiotherapy of chordoma.

Reduced dose-density of denosumab for maintenance therapy of unresectable giant cell tumor of bone: a multicenter phase II study "REDUCE"

The primary objective of the trial is to evaluate the risk versus benefit of denosumab in maintenance setting in patients requiring long-use (>1 year) of denosumab. For that purpose, the treatment schedule with reduced dose density (120mg SC…

A Multicenter, Open-label, Randomized Phase 2 Study to Compare the Efficacy and Safety of Lenvatinib in Combination with Ifosfamide and Etoposide versus Ifosfamide and Etoposide in Children, Adolescents and Young Adults with Relapsed or Refractory Osteosarcoma (OLIE)

Primary ObjectiveTo evaluate whether lenvatinib in combination with ifosfamide and etoposide (Arm A) is superior to ifosfamide and etoposide (Arm B) in improving progression-free survival (PFS) by independent imaging review [IIR] using Response…

PHASE 1/2 STUDY TO EVALUATE PALBOCICLIB (IBRANCE® ) IN
COMBINATION WITH IRINOTECAN AND TEMOZOLOMIDE AND/OR IN COMBINATION WITH TOPOTECAN AND CYCLOPHOSPHAMIDE IN
PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY SOLID
TUMORS

Primary: To compare the efficacy of palbociclib in combination with TMZ and IRN vs TMZ and IRN chemotherapy alone in the treatment of children, adolescents, and young adults with recurrent or refractory EWS.Secundary: To further compare the efficacy…

A phase 2, single arm, multi center trial evaluating the efficacy of the combination of sirolimus and cyclophosphamide in metastatic or unresectable myxoid liposarcoma and chondrosarcoma.

- To evaluate the treatment efficiency by time to progression according to RECIST 1.1

EWING 2008

Primary objectives:Standard Risk R1: in a randomised trial, to examine whether add-on treatment with fenretinide or zoledronic acid, or zoledronic acid plus fenretinide in addition to induction and maintenance chemotherapy improves event-free…