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Gait symmetry of patients with an endoprosthetic reconstruction of the knee joint after bone tumour resection.

The primary goal of this study is to describe possible causes of gait asymmetry in patients with an endoprosthetic reconstruction of the knee joint due to a bone tumour. Therefore, the assumed gait asymmetry is first verified (part A). Subsequently…

Reduced dose-density of denosumab for maintenance therapy of unresectable giant cell tumor of bone: a multicenter phase II study "REDUCE"

The primary objective of the trial is to evaluate the risk versus benefit of denosumab in maintenance setting in patients requiring long-use (>1 year) of denosumab. For that purpose, the treatment schedule with reduced dose density (120mg SC…