103 results
To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…
2 Objectives2.1 Primary objective •To evaluate FAZA-PET/CT as a prognostic factor of the loco-regional control rate at 2 years in HNSCC patients receiving chemo-radiotherapy ± nimorazole.•Time to locoregional recurrence is counted from the day of…
To identify the pathophysiology and predictors of study (extreme) cancer treatment -induced cardiovascular toxicity in cancer patients, by in vitro investigation of cardiovascular toxicity in patient-derived cardiomyocytes (iPSC-CMs) and endothelial…
The objective of this study is to Identify relevant geriatric instruments and compose a clinical model to predict tolerance and toxicity in elderly cancer patients who are treated with chemotherapy for their (metastasized) malignancy.
To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
To preserve testicular tissue of young boys with cancer for possible autologous transplantation in the future if infertility has become apparent.
Demonstrate an increase of 2-year overall survival (OS) of 15 % (from 50% to 65 %) vs historical controls of the addition of nitroglycerin to radiotherapy (±chemotherapy) of stage I-IV NSCLC.
Primary Objective:To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node…
To develop and evaluate the OncoActive+ project that aims to increase the amount of physical activity of (former) cancer patients. The main goal of this study is to test the effect of the intervention on physical activity behavior, as well as the…
Primary objective:To assess the safety, tolerability and pharmacokinetics of a single IV dosages of OTL-038. Selected doses of OTL-038 will be studied in the absence and presence of prophylactic treatment with the antihistamine clemastine to be…
To evaluate the effect of chemotherapy on the serological and cellular immune response to influenza virus vaccination in patients with breast or colorectal cancer in order to establisch the optimal timing of vaccination during treatment with…
An alternative for guide-wire localisation might be the use of radio-active seed (I-125) implantation. This marker can easily be identified by means of a gamma-probe. This radio-active seeds are cilindric capsules (approximately 4 mm with a diameter…
To study the diagnostic capacity of DW-MRI for detecting recurrence in patients with suspicion of recurrent or persistent HNSCC after initial (chemo)radiation. This study aims to enhance early, low cost detection of recurrence and avoid futile…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
To evaluate if a low-carbohydrate diet leeds to less physiological FDG-uptake in the myocard. Patients on a low-carbohydrate diet will be compared to patients without such a diet.
To investigate the optimal timepoint of replanning during a curative radio(chemo)therapy in patients with Head and Neck cancer. Furthermore we like to analyze if the optimal timepoint of replanning is depending on tumorlocation, tumor volume or…
- To determine the prevalence of (pre)cachexia - To determine whether potential biomarkers of pre-cachexia can be identified
Non invasive imaging of hypoxia with the aid of PET-scans could help to select the patients having a hypoxic tumor who could be treated with specific anti-hypoxic treatments. The added value of additional anti-hypoxic treatments depends on the…