100 results
To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…
2 Objectives2.1 Primary objective •To evaluate FAZA-PET/CT as a prognostic factor of the loco-regional control rate at 2 years in HNSCC patients receiving chemo-radiotherapy ± nimorazole.•Time to locoregional recurrence is counted from the day of…
Overall aim of the study is to investigate which decision-making models for patient participation are used in practice in end-of-life decision-making and how appropriate are these models for different patient groups.Secondary Objective(s): 1. In…
The aim of this project is to develop a comprehensive EORTC questionnaire for assessing sexual health for male and female patients with cancer. Given the lack of a sexual health related measure that can be used in clinical trials and in clinical…
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
The main objective of this study is to determine whether tumor concentrations of kinase inhibitors at pharmacological active doses can be predicted from PET studies using tracer amounts (microdosing) of corresponding radiolabeled kinase inhibitors.…
Demonstrate an increase of 2-year overall survival (OS) of 15 % (from 50% to 65 %) vs historical controls of the addition of nitroglycerin to radiotherapy (±chemotherapy) of stage I-IV NSCLC.
The primary objective is to test the feasibility of MRI measurements at 3T and 7T under dynamic hypercapnic or hyperoxic conditions controlled by digitally regulated respiratory challenges in volunteers.
Primary Objective:To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node…
Primary objective:To assess the safety, tolerability and pharmacokinetics of a single IV dosages of OTL-038. Selected doses of OTL-038 will be studied in the absence and presence of prophylactic treatment with the antihistamine clemastine to be…
To evaluate the validity of the SRT for assessing the exercise capacity of patients with cancer during chemotherapy.
1 To examine the differences in mindfulness between cancer patients and healthy references.2 To examine possible correlates of mindfulness, i.e. factors that may enhance or deplete mindfulness.3 To examine the relationship between mindfulness and…
An alternative for guide-wire localisation might be the use of radio-active seed (I-125) implantation. This marker can easily be identified by means of a gamma-probe. This radio-active seeds are cilindric capsules (approximately 4 mm with a diameter…
To study the diagnostic capacity of DW-MRI for detecting recurrence in patients with suspicion of recurrent or persistent HNSCC after initial (chemo)radiation. This study aims to enhance early, low cost detection of recurrence and avoid futile…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
To evaluate if a low-carbohydrate diet leeds to less physiological FDG-uptake in the myocard. Patients on a low-carbohydrate diet will be compared to patients without such a diet.
- To determine the prevalence of (pre)cachexia - To determine whether potential biomarkers of pre-cachexia can be identified
Non invasive imaging of hypoxia with the aid of PET-scans could help to select the patients having a hypoxic tumor who could be treated with specific anti-hypoxic treatments. The added value of additional anti-hypoxic treatments depends on the…
The primary aim of the study is to compare the performance of the standard oblique-viewing US endoscope versus a prototype forward viewing ultrasonic endoscope for EUS-FNA of solid lesions of the GI tract and of adjacent organs.